Infectious Disease Surveillance Center, National Institute of Infectious Diseases.
Department of Virology and Parasitology, Fujita Health University School of Medicine.
Jpn J Infect Dis. 2019 Jul 24;72(4):256-260. doi: 10.7883/yoken.JJID.2018.484. Epub 2019 Feb 28.
The emergence of unusual DS-1-like intergenogroup reassortant rotaviruses with a bovine-like G8 genotype (DS-1-like G8P[8] strains) has been reported in several Asian countries. During the rotavirus surveillance program in Japan in 2017, a DS-1-like G8P[8] strain (RVA/Human-wt/JPN/SO1162/2017/G8P[8]) was identified in 43 rotavirus-positive stool samples. Strain SO1162 was shown to have a unique genotype constellation, including genes from both genogroup 1 and 2: G8-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2. Phylogenetic analysis revealed that the VP1 gene of strain SO1162 appeared to have originated from DS-1-like G1P[8] strains from Thailand and Vietnam, while the remaining 10 genes were closely related to those of previously reported DS-1-like G8P[8] strains. Thus, SO1162 was suggested to be a reassortant strain that acquired the VP1 gene from Southeast Asian DS-1-like G1P[8] strains on the genetic background of co-circulating DS-1-like G8P[8] strains. Our findings provide important insights into the evolutionary dynamics of emerging DS-1-like G8P[8] strains.
在多个亚洲国家已经报道了具有牛样 G8 基因型（DS-1 样 G8P[8]株）的不寻常 DS-1 样 intergenogroup 重组轮状病毒的出现。在 2017 年日本的轮状病毒监测计划中，在 43 份轮状病毒阳性粪便样本中鉴定出了一种 DS-1 样 G8P[8]株（RVA/Human-wt/JPN/SO1162/2017/G8P[8]）。SO1162 株显示出独特的基因型组合，包括来自 1 型和 2 型基因群的基因：G8-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2。系统进化分析显示，SO1162 株的 VP1 基因似乎起源于来自泰国和越南的 DS-1 样 G1P[8]株，而其余 10 个基因与先前报道的 DS-1 样 G8P[8]株密切相关。因此，SO1162 被认为是一种重组株，它在流行的 DS-1 样 G8P[8]株的遗传背景上从东南亚 DS-1 样 G1P[8]株获得了 VP1 基因。我们的研究结果为新兴 DS-1 样 G8P[8]株的进化动态提供了重要的见解。
