Bartholome Odile, de la Brassinne Bonardeaux Orianne, Neirinckx Virginie, Rogister Bernard
GIGA-Neurosciences, University of Liege, 4000 Liège, Belgium.
Neurology Department, CHU, Academic Hospital, University of Liege, 4000 Liège, Belgium.
Cereb Cortex Commun. 2020 Jun 19;1(1):tgaa026. doi: 10.1093/texcom/tgaa026. eCollection 2020.
Parvalbumin-positive neurons are inhibitory neurons that release GABA and are mostly represented by fast-spiking basket or chandelier cells. They constitute a minor neuronal population, yet their peculiar profiles allow them to react quickly to any event in the brain under normal or pathological conditions. In this review, we will summarize the current knowledge about the fundamentals of fast-spiking parvalbumin-positive neurons, focusing on their morphology and specific channel/protein content. Next, we will explore their development, maturation, and migration in the brain. Finally, we will unravel their potential contribution to the physiopathology of epilepsy.
小清蛋白阳性神经元是释放γ-氨基丁酸（GABA）的抑制性神经元，主要由快速放电的篮状细胞或吊灯细胞代表。它们构成了一小部分神经元群体，然而其独特的特征使它们能够在正常或病理条件下对大脑中的任何事件迅速做出反应。在这篇综述中，我们将总结关于快速放电的小清蛋白阳性神经元基本特性的现有知识，重点关注它们的形态和特定的通道/蛋白质含量。接下来，我们将探讨它们在大脑中的发育、成熟和迁移。最后，我们将揭示它们对癫痫生理病理学的潜在贡献。
