Abu-Farha Mohamed, Al Madhoun Ashraf, Abubaker Jehad
Biochemistry and Molecular Biology Unit, Dasman Diabetes Institute, Kuwait City, Kuwait.
Research Division, Dasman Diabetes Institute, Kuwait City, Kuwait.
J Diabetes Res. 2016;2016:4860595. doi: 10.1155/2016/4860595. Epub 2016 Sep 8.
Diabetes is a global health problem that is caused by impaired insulin production from pancreatic -cells. Efforts to regenerate -cells have been advancing rapidly in the past two decades with progress made towards identifying new agents that induce -cells regeneration. ANGPTL8, also named betatrophin, has been recently identified as a hormone capable of inducing -cells proliferation and increasing -cells mass in rodents. Its discovery has been cherished as a breakthrough and a game changer in the field of -cells regeneration. Initially, ANGPTL8 has been identified as atypical member of the angiopoietin-like protein family as a regulator of triglyceride in plasma through its interaction with ANGPTL3 and its regulation of lipoprotein lipase activity. In this review, we will review literature on the proposed role of ANGPTL8 in -cells proliferation, the controversy regarding this role, and the emerging data questioning its involvement in -cells proliferation. Additionally we will discuss new clinical data that describes its role in diabetes and the putative therapeutic targeting of this protein.
糖尿病是一个全球性的健康问题，由胰腺β细胞胰岛素分泌受损引起。在过去二十年中，β细胞再生的研究进展迅速，在识别诱导β细胞再生的新药物方面取得了进展。血管生成素样蛋白8（ANGPTL8），也称为β细胞营养因子，最近被确定为一种能够诱导啮齿动物β细胞增殖并增加β细胞数量的激素。它的发现被誉为β细胞再生领域的一项突破和变革。最初，ANGPTL8被确定为血管生成素样蛋白家族的非典型成员，通过与ANGPTL3相互作用及其对脂蛋白脂肪酶活性的调节，作为血浆中甘油三酯的调节剂。在这篇综述中，我们将回顾关于ANGPTL8在β细胞增殖中所起作用的文献、关于这一作用的争议，以及质疑其参与β细胞增殖的新出现的数据。此外，我们将讨论描述其在糖尿病中的作用以及该蛋白潜在治疗靶点的新临床数据。
