Pan Ruirong, Zhang Haiming, Yu Shuping, Deng Jialiang, Ma Suxian, Li Yanyan, Yuan Guoyue, Wang Jifang
1 Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
3 Department of Clinical Nutrition, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
J Int Med Res. 2019 Feb;47(2):710-717. doi: 10.1177/0300060518808683. Epub 2018 Nov 5.
Betatrophin is a widely used diagnostic marker for type 2 diabetes mellitus (DM), but its clinical utility in diagnosing gestational DM (GDM) is unclear. We evaluated the relationship between betatrophin and the risk of GDM as well as the ability of betatrophin to predict postpartum type 2 DM (PDM).
In total, 386 patients were categorized into those with and without PDM. All underwent the oral glucose tolerance test while pregnant. Betatrophin was assessed to examine the diagnostic characteristics of GDM.
The betatrophin concentration was remarkably higher in patients with than without GDM. The patients were categorized into three groups; those with a betatrophin concentration of 300 to 600 pg/mL and >600 pg/mL had a higher risk of GDM after adjusting for body mass index, age, homeostatic model assessment-insulin resistance (HOMA-IR) concentration, and betatrophin concentration than those with a betatrophin concentration of <300 pg/mL. The HOMA-IR concentration tended to increase as the betatrophin concentration increased, and betatrophin was independently associated with GDM after adjusting for confounders. The betatrophin concentration was higher among pregnant patients with than without PDM.
Betatrophin has high sensitivity but low specificity for diagnosing GDM and may be a promising predictor of PDM.
β细胞素是2型糖尿病（DM）广泛应用的诊断标志物，但其在诊断妊娠期糖尿病（GDM）中的临床效用尚不清楚。我们评估了β细胞素与GDM风险之间的关系以及β细胞素预测产后2型糖尿病（PDM）的能力。
总共386例患者被分为有或无PDM两组。所有患者在孕期均接受口服葡萄糖耐量试验。评估β细胞素以检查GDM的诊断特征。
GDM患者的β细胞素浓度显著高于非GDM患者。患者被分为三组；在调整体重指数、年龄、稳态模型评估胰岛素抵抗（HOMA-IR）浓度和β细胞素浓度后，β细胞素浓度为300至600 pg/mL和>600 pg/mL的患者患GDM的风险高于β细胞素浓度<300 pg/mL的患者。随着β细胞素浓度升高，HOMA-IR浓度有升高趋势，在调整混杂因素后，β细胞素与GDM独立相关。有PDM的孕妇的β细胞素浓度高于无PDM的孕妇。
β细胞素在诊断GDM方面具有高敏感性但低特异性，可能是PDM的一个有前景的预测指标。
