健康年轻人群中维生素D受体基因多态性、心血管危险因素与脂联素之间的关系
Relationship between vitamin D receptor gene polymorphisms, cardiovascular risk factors and adiponectin in a healthy young population.
作者信息
Hajj Aline, Chedid Rima, Chouery Eliane, Megarbané André, Gannagé-Yared Marie-Hélène
机构信息
Laboratoire de Pharmacologie, Pharmacie clinique et Contrôle de Qualité des médicaments, Pôle Technologie- Santé (PTS), Faculty of Pharmacy, Saint-Joseph University, Beirut, Lebanon.
Genetics Medical Unit, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.
出版信息
Pharmacogenomics. 2016 Oct;17(15):1675-1686. doi: 10.2217/pgs-2016-0045. Epub 2016 Sep 27.
AIM
To explore the association between VDR polymorphisms and several cardiovascular risk factors and adiponectin.
MATERIALS & METHODS: Three-hundred and sixty-nine healthy students were randomly selected. Five VDR polymorphisms were genotyped: BsmI rs1544410; Cdx2 rs11568820; ApaI rs7975232; TaqI rs731236 and FokI rs2228570. BMI, waist circumference (WC), blood pressure, lipid/glycemic profiles and adiponectin were assessed.
RESULTS
In men, BsmI, ApaI and TaqI were associated with BMI and WC (p < 0.05). FokI was associated with triglycerides and high-density lipoprotein levels (p = 0.0036; p = 0.005) whereas BsmI and Cdx2 were associated with adiponectin levels (p = 0.026; p = 0.048). Associations disappeared after BMI and WC adjustments. In women, ApaI was associated with systolic blood pressure (p = 0.02).
CONCLUSION
Our study demonstrated a gender-specific difference between VDR SNPs and various cardiovascular risk factors and adiponectin.
目的
探讨维生素D受体（VDR）基因多态性与多种心血管危险因素及脂联素之间的关联。
材料与方法
随机选取369名健康学生。对5种VDR基因多态性进行基因分型：BsmI rs1544410；Cdx2 rs11568820；ApaI rs7975232；TaqI rs731236和FokI rs2228570。评估体重指数（BMI）、腰围（WC）、血压、血脂/血糖谱和脂联素。
结果
在男性中，BsmI、ApaI和TaqI与BMI和WC相关（p<0.05）。FokI与甘油三酯和高密度脂蛋白水平相关（p=0.0036；p=0.005），而BsmI和Cdx2与脂联素水平相关（p=0.026；p=0.048）。在调整BMI和WC后，这些关联消失。在女性中，ApaI与收缩压相关（p=0.02）。
结论
我们的研究表明VDR单核苷酸多态性（SNPs）与各种心血管危险因素及脂联素之间存在性别特异性差异。
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