染色质对发育动力学和可塑性的调控。

Chromatin Control of Developmental Dynamics and Plasticity.

机构信息

Radboud University, Faculty of Science, Department of Molecular Developmental Biology, Radboud Institute for Molecular Life Sciences, 6500 HB Nijmegen, the Netherlands.

出版信息

Dev Cell. 2016 Sep 26;38(6):610-20. doi: 10.1016/j.devcel.2016.08.004.

DOI:10.1016/j.devcel.2016.08.004

PMID:27676434

Abstract

Chromatin structure is intimately connected with gene expression and cell identity. Here we review recent advances in the field and discuss how establishment of cell identity during development is accompanied by large-scale remodeling of the epigenetic landscape and how this remodeling drives and supports lineage specification and maintenance. We discuss maternal control of the early embryonic epigenetic landscape, selective usage of enhancer clusters via 3D chromatin contacts leading to activation of transcription factor networks, and conserved regulation of developmental pathways by specific DNA demethylation of key regulatory regions. Together, these processes establish an epigenetic framework regulating different phases of embryonic development.

摘要

染色质结构与基因表达和细胞身份密切相关。在这里，我们回顾了该领域的最新进展，并讨论了在发育过程中建立细胞身份时，表观遗传景观如何发生大规模重塑，以及这种重塑如何驱动和支持谱系特化和维持。我们讨论了母源对早期胚胎表观遗传景观的控制，通过 3D 染色质接触选择性使用增强子簇导致转录因子网络的激活，以及特定关键调控区域的 DNA 去甲基化对发育途径的保守调控。这些过程共同建立了一个调节胚胎发育不同阶段的表观遗传框架。