Yoshikata Remi, Myint Khin Z, Ohta Hiroaki
1Hamasite Clinic, Tokyo, Japan 2Tokyo Midtown Medical Center, Tokyo, Japan 3Sanno Medical Center, Minato-ku, Tokyo, Japan.
Menopause. 2017 Feb;24(2):216-224. doi: 10.1097/GME.0000000000000743.
Equol, an active metabolite possessing estrogen-like activity, is produced by the action of intestinal flora on soy isoflavones. There is an increasing evidence regarding its efficacy in the relief of menopausal symptoms, suppression of decreased bone mineral density, and lipid profile improvement. Only those with equol-producing capacity, however, seem to benefit. Thus, we examined the relationship between equol producer status and parameters associated with lifestyle-related diseases in women from their 20s to 80s.
This cross-sectional study was conducted among 743 women (21-89 y; average age: 52.5 ± 11.8 y) who have undergone health screening at Tokyo Midtown Medical Center and given consent to participate in the study. The relationship between equol producer status and metabolic parameters was assessed.
In our study, 236 women (32%) were equol producers. Equol producers had significantly lower triglycerides and higher high-density lipoprotein cholesterol levels compared with nonproducers. Equol-producing women in their 50s showed significantly lower body fat level, visceral fat area, triglyceride levels, pulse wave velocity, uric acid levels, and high sensitivity C-reactive protein levels. In addition, women in their 60s showed significantly higher levels of high-density lipoprotein cholesterol. In multivariate logistic regression, for women in their 50s, equol production was significantly associated with lower arterial stiffness and uric acid levels, and a high ratio of eicosapentaenoic acid to arachidonic acid, whereas it was significantly associated with lower urinary N-telopeptides in their 60s.
Equol producer status was associated with favorable metabolic parameters, in women in the early phase postmenopause, with the transitional periods noted with declining intrinsic estrogen levels.
雌马酚是一种具有雌激素样活性的活性代谢产物，由肠道菌群对大豆异黄酮的作用产生。越来越多的证据表明其在缓解更年期症状、抑制骨矿物质密度下降和改善血脂方面具有功效。然而，似乎只有那些具有雌马酚产生能力的人才能受益。因此，我们研究了20多岁至80多岁女性中雌马酚产生状态与生活方式相关疾病相关参数之间的关系。
这项横断面研究是在743名女性（21 - 89岁；平均年龄：52.5±11.8岁）中进行的，这些女性在东京中城医疗中心接受了健康筛查并同意参与该研究。评估了雌马酚产生状态与代谢参数之间的关系。
在我们的研究中，236名女性（32%）是雌马酚生产者。与非生产者相比，雌马酚生产者的甘油三酯水平显著较低，高密度脂蛋白胆固醇水平较高。50多岁的雌马酚产生女性的体脂水平、内脏脂肪面积、甘油三酯水平、脉搏波速度、尿酸水平和高敏C反应蛋白水平显著较低。此外，60多岁的女性高密度脂蛋白胆固醇水平显著较高。在多因素逻辑回归中，对于50多岁的女性，雌马酚产生与较低的动脉僵硬度和尿酸水平以及二十碳五烯酸与花生四烯酸的高比例显著相关，而对于60多岁的女性，它与较低的尿N - 端肽显著相关。
在绝经后早期的女性中，雌马酚产生状态与良好的代谢参数相关，这些时期伴随着内源性雌激素水平的下降。
