Koenderman L, Bruijnzeel P L
Department of Pulmonary Disease, State University Hospital Utrecht, The Netherlands.
Immunology. 1989 Aug;67(4):534-6.
Eosinophilia in peripheral blood is a common phenomenon associated with atopic condition. The present study illustrates the enhanced sensitivity of these eosinophils for formyl-methionyl-leucylphenylalanine (FMLP) and platelet-activating-factor (PAF) (measured as luminol-enhanced chemiluminescence) compared with eosinophils isolated from the peripheral blood of normal individuals. The PAF-induced chemiluminescence, which is peroxidase dependent and of extracellular origin, is inhibited by the PAF antagonist BN52021. The enhanced sensitivity of eosinophils isolated from atopic patients for FMLP and PAF might reflect a 'primed' state of these cells, relevant for the pathogenesis of atopic disease.
外周血嗜酸性粒细胞增多是一种与特应性疾病相关的常见现象。本研究表明，与从正常个体外周血中分离出的嗜酸性粒细胞相比，这些嗜酸性粒细胞对甲酰甲硫氨酰亮氨酰苯丙氨酸（FMLP）和血小板活化因子（PAF）的敏感性增强（以鲁米诺增强化学发光法测定）。PAF诱导的化学发光依赖过氧化物酶且起源于细胞外，被PAF拮抗剂BN52021抑制。从特应性患者分离出的嗜酸性粒细胞对FMLP和PAF的敏感性增强可能反映了这些细胞的“预激”状态，这与特应性疾病的发病机制相关。
