López Zunini Rocío A, Knoefel Frank, Lord Courtney, Dzuali Fiatsogbe, Breau Michael, Sweet Lisa, Goubran Rafik, Taler Vanessa
University of Ottawa, School of Psychology, Vanier Hall, 136 Jean Jacques Lussier, Ottawa, ON K1N 6N5, Canada; Bruyère Research Institute, 75 Bruyère St., Ottawa, ON K1N 5C8, Canada.
Bruyère Research Institute, 75 Bruyère St., Ottawa, ON K1N 5C8, Canada; Bruyère Memory Program, Bruyère Continuing Care, 43 Bruyère St, Ottawa, ON K1N 5C8, Canada; Carleton University, Faculty of Engineering and Design, 3010 The Minto Centre, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada; University of Ottawa, Faculty of Medicine, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.
Int J Psychophysiol. 2016 Nov;109:1-8. doi: 10.1016/j.ijpsycho.2016.09.012. Epub 2016 Sep 24.
Persons with Mild Cognitive Impairment (MCI) can experience deficits in working memory. In the present study, we investigated working memory in persons with MCI and cognitively healthy older adults using event-related potentials (ERPs). Participants performed an n-back working memory task with baseline (0-back), low load (1-back), and high load (2-back) working memory conditions. MCI participants' performance was less accurate than that of healthy older adults in both the 1-back and 2-back conditions, and reaction times were longer in MCI than control participants in the 0-back, 1-back and 2-back conditions. ERP analyses revealed delayed P200 and N200 latencies and smaller P300 amplitudes in MCI relative to control participants in the 0-back, 1-back and 2-back conditions. Deterioration in working memory performance concomitant with marked electrophysiological alterations suggests that persons with MCI exhibit deficits in several cognitive processes that include early attention, stimulus discrimination and classification, and updating and manipulation of information held in working memory.
轻度认知障碍（MCI）患者可能会出现工作记忆缺陷。在本研究中，我们使用事件相关电位（ERP）对MCI患者和认知健康的老年人的工作记忆进行了调查。参与者在基线（0-back）、低负荷（1-back）和高负荷（2-back）工作记忆条件下执行n-back工作记忆任务。在1-back和2-back条件下，MCI参与者的表现不如健康老年人准确，并且在0-back、1-back和2-back条件下，MCI参与者的反应时间比对照组参与者更长。ERP分析显示，在0-back、1-back和2-back条件下，与对照组相比，MCI患者的P200和N200潜伏期延迟，P300波幅较小。工作记忆表现的恶化与明显的电生理改变同时出现，这表明MCI患者在包括早期注意力、刺激辨别和分类以及工作记忆中信息的更新和操作等多个认知过程中存在缺陷。
