胆碱能调制在位置和运动速度神经编码中的潜在作用。
Potential roles of cholinergic modulation in the neural coding of location and movement speed.
作者信息
Dannenberg Holger, Hinman James R, Hasselmo Michael E
机构信息
Center for Systems Neuroscience, Department of Psychological and Brain Sciences, Center for Memory and Brain, Graduate Program for Neuroscience, Boston University, 2 Cummington Mall, Boston, MA 02215, USA.
出版信息
J Physiol Paris. 2016 Sep;110(1-2):52-64. doi: 10.1016/j.jphysparis.2016.09.002. Epub 2016 Sep 24.
Behavioral data suggest that cholinergic modulation may play a role in certain aspects of spatial memory, and neurophysiological data demonstrate neurons that fire in response to spatial dimensions, including grid cells and place cells that respond on the basis of location and running speed. These neurons show firing responses that depend upon the visual configuration of the environment, due to coding in visually-responsive regions of the neocortex. This review focuses on the physiological effects of acetylcholine that may influence the sensory coding of spatial dimensions relevant to behavior. In particular, the local circuit effects of acetylcholine within the cortex regulate the influence of sensory input relative to internal memory representations via presynaptic inhibition of excitatory and inhibitory synaptic transmission, and the modulation of intrinsic currents in cortical excitatory and inhibitory neurons. In addition, circuit effects of acetylcholine regulate the dynamics of cortical circuits including oscillations at theta and gamma frequencies. These effects of acetylcholine on local circuits and network dynamics could underlie the role of acetylcholine in coding of spatial information for the performance of spatial memory tasks.
行为学数据表明，胆碱能调节可能在空间记忆的某些方面发挥作用，神经生理学数据则证明，存在对空间维度做出反应而放电的神经元，包括基于位置和奔跑速度做出反应的网格细胞和位置细胞。由于新皮层视觉反应区域的编码作用，这些神经元的放电反应取决于环境的视觉配置。本综述聚焦于乙酰胆碱可能影响与行为相关的空间维度感觉编码的生理效应。特别是，皮层内乙酰胆碱的局部回路效应通过对兴奋性和抑制性突触传递的突触前抑制以及对皮层兴奋性和抑制性神经元内在电流的调制，调节感觉输入相对于内部记忆表征的影响。此外，乙酰胆碱的回路效应调节皮层回路的动力学，包括theta和gamma频率的振荡。乙酰胆碱对局部回路和网络动力学的这些效应可能是乙酰胆碱在为空间记忆任务的执行进行空间信息编码中发挥作用的基础。
Zotero 插件