Eapen E, Grey V, Don-Wauchope A, Atkinson S A
Department of Pathology and Molecular Medicine, McMaster University , Hamilton, ON, Canada.
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada; Department of Pediatrics, McMaster University, Hamilton, ON, Canada.
EJIFCC. 2008 Oct 16;19(2):123-36. eCollection 2008 Oct.
Development of the human skeleton begins in early embryonic life and continues through childhood into early adulthood. The acquisition of peak bone mass during these vulnerable periods may impact on skeletal fragility in later adult years. Once the skeleton has reached maturity, bone remodelling continues with periodic replacement of old bone with new at the same location. Bone biomarkers are specifically derived biomarkers that reflect both formation by osteoblasts and resorption by osteoclasts. Children have significantly higher concentrations of bone biomarkers than adults due to both skeletal growth and rapid bone turnover during childhood and adolescence. Biochemical assessment of markers of bone turnover may be important in the diagnosis, prognosis and management of metabolic bone disease. This review will discuss the various serum bone markers used for assessing bone health and the factors that influence their utility.
人类骨骼的发育始于胚胎早期，并持续贯穿儿童期直至成年早期。在这些易受影响的时期获得峰值骨量可能会影响成年后期骨骼的脆弱性。一旦骨骼成熟，骨重塑会持续进行，旧骨会在同一位置定期被新骨替代。骨生物标志物是特定的衍生生物标志物，反映成骨细胞的形成和破骨细胞的吸收。由于儿童期和青春期的骨骼生长以及快速的骨转换，儿童的骨生物标志物浓度明显高于成年人。骨转换标志物的生化评估在代谢性骨病的诊断、预后和管理中可能很重要。本综述将讨论用于评估骨骼健康的各种血清骨标志物以及影响其效用的因素。
