Schumacher Soeren, Sartorius Dorian, Ehrentreich-Förster Eva, Bier Frank F
EJIFCC. 2012 Oct 12;23(3):70-5. eCollection 2012 Oct.
Platform technologies for the changing need of diagnostics are one of the main challenges in medical device technology. From one point-of-view the demand for new and more versatile diagnostic is increasing due to a deeper knowledge of biomarkers and their combination with diseases. From another point-of-view a decentralization of diagnostics will occur since decisions can be made faster resulting in higher success of therapy. Hence, new types of technologies have to be established which enables a multiparameter analysis at the point-of-care. Within this review-like article a system called Fraunhofer ivD-platform is introduced. It consists of a credit-card sized cartridge with integrated reagents, sensors and pumps and a read-out/processing unit. Within the cartridge the assay runs fully automated within 15-20 minutes. Due to the open design of the platform different analyses such as antibody, serological or DNA-assays can be performed. Specific examples of these three different assay types are given to show the broad applicability of the system.
适应诊断需求变化的平台技术是医疗设备技术面临的主要挑战之一。从一个角度来看，由于对生物标志物及其与疾病的关联有了更深入的了解，对新型且更具通用性诊断方法的需求正在增加。从另一个角度来看，诊断将走向分散化，因为决策能够更快做出，从而提高治疗成功率。因此，必须建立新型技术，以实现即时护理点的多参数分析。在这篇类似综述的文章中，介绍了一种名为弗劳恩霍夫体外诊断平台的系统。它由一个信用卡大小的盒式装置组成，该装置集成了试剂、传感器和泵以及一个读出/处理单元。在盒式装置内，检测在15至20分钟内完全自动化运行。由于该平台的开放式设计，可以进行不同的分析，如抗体、血清学或DNA检测。给出了这三种不同检测类型的具体示例，以展示该系统的广泛适用性。
