Fraunhofer Institute for Biomedical Engineering IBMT, Branch Potsdam, Am Mühlenberg 13, 14476, Potsdam, Germany,
Adv Biochem Eng Biotechnol. 2013;133:75-87. doi: 10.1007/10_2012_165.
It is believed Lab-on-Chip systems will become a mainstream technology within the next centuries. Especially because of new findings in molecular medicine and global trends such as the changing global population in third world countries and an ageing population in industrial countries, the need for fast and reliable diagnostics is rising tremendously. Hence, diagnostics have to become more frequently and more easily available. In this regard, technologies have to be found that enable the cost-effective production and hence an affordable price. In a joint-project between seven Fraunhofer institutes a Lab-on-Chip system was developed which consists of a credit-card-sized cartridge and a base station. The cartridges contain besides the reagents necessary for a specific assay also functionalities such as pumping or heating enabling a self-contained system without any fluidic interfaces, which tend to be error-prone. Because of the modularity of the system it is possible to integrate an optical sensor as well an electrochemical sensor into the cartridge. Hence, the system can be customized to serve the needs of the particular assays. This chapter will describe the system including generic design rules for such Lab-on-Chip systems, the development of these rules into a modular Lab-on-Chip system, the integration of biomedical assays, and the production possibility of this system.
人们相信，在未来几个世纪里，芯片实验室系统将成为主流技术。特别是由于分子医学的新发现以及全球趋势，如第三世界国家人口的变化和工业化国家人口的老龄化，对快速可靠诊断的需求正在大幅增长。因此，诊断必须更加频繁和更容易获得。在这方面，必须找到能够实现具有成本效益的生产从而实现价格合理的技术。在七个弗劳恩霍夫研究所的联合项目中，开发了一种由信用卡大小的盒式元件和一个基座组成的芯片实验室系统。这些盒式元件除了包含特定测定所需的试剂外，还具有例如泵送或加热等功能，从而实现了无需任何易出错的流体接口的自给式系统。由于系统的模块化，因此可以将光学传感器和电化学传感器集成到盒式元件中。因此，该系统可以根据特定测定的需求进行定制。本章将描述该系统，包括此类芯片实验室系统的通用设计规则，将这些规则开发成模块化的芯片实验室系统，生物医学测定的集成以及该系统的生产可能性。
