Zhu Yuncheng, Yang Daoliang, Ji Weidong, Huang Tianming, Xue Lianxue, Jiang Xixi, Chen Liangliang, Wang Fang
Shanghai Changning District Mental Health Center, Green Land Hospital of Bio-X Center, Shanghai Jiaotong University, Shanghai 200335, China.
Biomed Res Int. 2016;2016:3821579. doi: 10.1155/2016/3821579. Epub 2016 Sep 1.
The prefrontal cortex is the superlative structure of brain that needs the longest developmental and maturational duration that highlights the region of attention deficit hyperactivity disorder (ADHD) in neuroimaging studies. Prefrontal cortex functions generate enormously complex and its abundant feedback neurocircuitries with subcortical structures such as striatum and thalamus established through dual neural fibers. These microneurocircuitries are called corticostriatothalamocortical (CSTC) circuits. The CSTC circuits paly an essential role in flexible behaviors. The impaired circuits increase the risk of behavioral and psychological symptoms. ADHD is an especial developmental stage of paediatric disease. It has been reported that the CSTC circuits dysfunctions in ADHD are related to homologous symptoms. This study aimed to review the symptoms of ADHD and discuss the recent advances on the effects of the disease as well as the new progress of treatments with each circuit.
前额叶皮质是大脑中最高级的结构，其发育和成熟所需的时间最长，这在神经影像学研究中突出了注意力缺陷多动障碍（ADHD）的区域。前额叶皮质的功能极其复杂，它通过双神经纤维与纹状体和丘脑等皮质下结构建立了丰富的反馈神经回路。这些微神经回路被称为皮质-纹状体-丘脑-皮质（CSTC）回路。CSTC回路在灵活行为中起着至关重要的作用。受损的回路会增加行为和心理症状的风险。ADHD是儿科疾病的一个特殊发育阶段。据报道，ADHD中CSTC回路功能障碍与同源症状有关。本研究旨在综述ADHD的症状，讨论该疾病影响方面的最新进展以及各回路治疗的新进展。
