Silveira Célia M, Monteiro Tiago, Almeida Maria Gabriela
UCIBIO, REQUIMTE, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Monte de Caparica, Portugal.
Instituto de Tecnologia Química e Biológica António Xavier, Universidade NOVA de Lisboa, Av. da República, 2780-157 Oeiras, Portugal.
Biosensors (Basel). 2016 Sep 28;6(4):51. doi: 10.3390/bios6040051.
From the bench-mark work on microfluidics from the Whitesides's group in 2007, paper technology has experienced significant growth, particularly regarding applications in biomedical research and clinical diagnostics. Besides the structural properties supporting microfluidics, other advantageous features of paper materials, including their versatility, disposability and low cost, show off the great potential for the development of advanced and eco-friendly analytical tools. Consequently, paper was quickly employed in the field of electrochemical sensors, being an ideal material for producing custom, tailored and miniaturized devices. Stencil-, inkjet-, or screen-printing are the preferential techniques for electrode manufacturing. Not surprisingly, we witnessed a rapid increase in the number of publications on paper based screen-printed sensors at the turn of the past decade. Among the sensing strategies, various biosensors, coupling electrochemical detectors with biomolecules, have been proposed. This work provides a critical review and a discussion on the future progress of paper technology in the context of miniaturized printed electrochemical biosensors.
自2007年怀特塞兹团队开展微流控基准工作以来，纸质技术取得了显著发展，尤其是在生物医学研究和临床诊断中的应用。除了支持微流控的结构特性外，纸质材料的其他优势特性，包括多功能性、一次性使用和低成本，展现了其在先进且环保的分析工具开发方面的巨大潜力。因此，纸材很快被应用于电化学传感器领域，成为制造定制化、个性化和小型化设备的理想材料。模板印刷、喷墨印刷或丝网印刷是制造电极的首选技术。不出所料，在过去十年之交，我们见证了基于纸材的丝网印刷传感器相关出版物数量的迅速增加。在传感策略方面，已经提出了各种将电化学检测器与生物分子相结合的生物传感器。本文对小型化印刷电化学生物传感器背景下纸质技术的未来进展进行了批判性综述和讨论。
