HOTAIR基因rs920778多态性与中国人群卵巢癌易感性及不良预后相关。
HOTAIR rs920778 polymorphism is associated with ovarian cancer susceptibility and poor prognosis in a Chinese population.
作者信息
Qiu Haifeng, Wang Xiujuan, Guo Ruixia, Liu Qiuli, Wang Yuan, Yuan Zhongfu, Li Jing, Shi Huirong
机构信息
Department of Obstetrics & Gynecology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Ovarian & Cervical Disease Clinical Treatment Center of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
出版信息
Future Oncol. 2017 Feb;13(4):347-355. doi: 10.2217/fon-2016-0290. Epub 2016 Oct 3.
AIM
The aim of this study was to determine if HOTAIR rs920778 polymorphism is associated with ovarian cancer susceptibility and prognosis.
MATERIALS & METHODS: The data were obtained from two independent groups including 329 ovarian cancer patients and 680 cancer-free, age-matched women. Blood samples were collected and genomic DNA was extracted for genotyping.
RESULTS
TT genotype and T allele of HOTAIR rs920778 were significantly associated with a decreased ovarian cancer risk (p = 0.0004 and p < 0.0001, respectively), which associated with advanced tumor stage, lymph node metastasis and poor prognosis. Moreover, TT and TC carriers obtained a much shorter survival (p = 0.026).
CONCLUSION
These findings propose that HOTAIR rs920778 polymorphism influences ovarian cancer susceptibility and prognosis, and further studies are warranted in other populations.
目的
本研究旨在确定HOTAIR基因rs920778多态性是否与卵巢癌易感性及预后相关。
材料与方法
数据来自两个独立组，包括329例卵巢癌患者和680例年龄匹配的无癌女性。采集血样并提取基因组DNA进行基因分型。
结果
HOTAIR基因rs920778的TT基因型和T等位基因与卵巢癌风险降低显著相关（分别为p = 0.0004和p < 0.0001），这与肿瘤晚期、淋巴结转移及预后不良相关。此外，TT和TC携带者的生存期明显更短（p = 0.026）。
结论
这些发现表明HOTAIR基因rs920778多态性影响卵巢癌易感性和预后，其他人群有必要进一步研究。
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