Canguven Onder, Talib Raidh A, El-Ansari Walid, Shamsoddini Ahmed, Salman Mahmoud, Al-Ansari Abdulla
a Department of Urology , Hamad Medical Corporation , Doha , Qatar.
b Weill Cornell Medical College in Qatar , Doha , Qatar.
Aging Male. 2016 Dec;19(4):215-220. doi: 10.1080/13685538.2016.1230602. Epub 2016 Oct 1.
Late-onset hypogonadism (LOH) presents with low serum testosterone (TT) levels and sexual and nonsexual symptoms. Erectile dysfunction affects a man's self-esteem and as a result partner relationship and quality of life.
To investigate the andrological clinical profile outcomes of testosterone therapy (TTh) in men (n = 88) with symptomatic LOH complaints and symptoms.
Erectile function was assessed using the International Index of Erectile Function-5 questionnaire at baseline and at 6 and 12 months of TTh. In addition, penile length was measured at baseline and 12 months. We also evaluated nocturnal penile tumescence (NPT, using RigiScan) and blood flow of cavernous arteries (penile Doppler ultrasonography) at baseline and 12 months of TT.
Eighty-eight LOH men (M 51.1 years) with erectile dysfunction, all with serum TT <10.4 nmol/L before TTh. Patients received intramuscular long-acting testosterone undecanoate for 12 months.
Following TTh, in all patients, serum TT levels were restored within 3 months to normal levels. Compared with baseline values, erectile function significantly improved at 6 (mean score increase 1.95) and 12 months (mean score increase 2.16). No significant changes in penile length were observed. NPT significantly improved at 12 months in terms of both the frequency (mean increase 1.27 times) and duration of rigidity (mean increase 5.12 min). As regards the blood flow of the cavernous arteries, we observed a significant improvement (decrease of 1.16 cm/s) and end diastolic velocity of the penile arteries.
TTh in men with LOH resulted in improvement of the erectile function, NPT, and to some extent the blood flow of the cavernous arteries.
迟发性性腺功能减退（LOH）表现为血清睾酮（TT）水平低下以及性和非性症状。勃起功能障碍会影响男性的自尊，进而影响伴侣关系和生活质量。
研究睾酮治疗（TTh）对88例有症状性LOH主诉和症状男性的男科临床特征结局。
在基线以及TTh治疗6个月和12个月时，使用国际勃起功能指数-5问卷评估勃起功能。此外，在基线和12个月时测量阴茎长度。我们还在基线和TT治疗12个月时评估夜间阴茎勃起（NPT，使用RigiScan）和海绵体动脉血流（阴茎多普勒超声检查）。
88例患有勃起功能障碍的LOH男性（平均年龄51.1岁），TTh治疗前血清TT均<10.4 nmol/L。患者接受肌肉注射长效十一酸睾酮12个月。
TTh治疗后，所有患者的血清TT水平在3个月内恢复至正常水平。与基线值相比，勃起功能在6个月（平均评分增加1.95）和12个月（平均评分增加2.16）时显著改善。未观察到阴茎长度有显著变化。NPT在12个月时，无论是频率（平均增加1.27倍）还是勃起持续时间（平均增加5.12分钟）均显著改善。关于海绵体动脉血流，我们观察到阴茎动脉的血流有显著改善（降低1.16 cm/s）和舒张末期流速。
LOH男性的TTh治疗可改善勃起功能、NPT，并在一定程度上改善海绵体动脉血流。
