Martony Molly E, Krause Kristian J, Weldy Scott H, Simpson Stephen A
J Zoo Wildl Med. 2016 Sep;47(3):923-926. doi: 10.1638/2015-0053.1.
Successful xenotransfusion in an island fox ( Urocyon littoralis clementae) has not been previously reported but may be necessary in an emergency. An 11-yr-old male, intact, captive island fox was exhibiting clinical signs of rattlesnake envenomation including hypoperfusion, tachypnea, facial edema, and multifocal facial and cervical ecchymosis. Blood work revealed severe thrombocytopenia (18 K/μl) and anemia (Hct 15.8%). A presumptive diagnosis of rattlesnake ( Crotalus sp.) envenomation was made. Initial treatment included oxygen therapy, fluid therapy, antibiotics, antacids, pain medications, and polyvalent crotalid anti-venom. Emergency xenotransfusion using whole blood (45 ml) from a domestic dog was used due to worsening clinical signs from anemia. No acute or delayed transfusion reactions were observed in the fox and the patient made a full recovery 5 days later. Successful xenotransfusion in an island fox using whole blood from a domestic dog ( Canis lupus familiaris) is possible and may be lifesaving.
此前尚未有关于海岛灰狐（Urocyon littoralis clementae）成功进行异种输血的报道，但在紧急情况下可能有必要进行。一只11岁的雄性、未绝育的圈养海岛灰狐出现了响尾蛇中毒的临床症状，包括灌注不足、呼吸急促、面部水肿以及多灶性面部和颈部瘀斑。血液检查显示严重血小板减少（18 K/μl）和贫血（血细胞比容15.8%）。初步诊断为响尾蛇（Crotalus sp.）中毒。初始治疗包括氧疗、液体疗法、抗生素、抗酸剂、止痛药物和多价响尾蛇抗蛇毒血清。由于贫血导致临床症状恶化，使用了来自家犬的全血（45毫升）进行紧急异种输血。在这只狐狸身上未观察到急性或延迟输血反应，该患者在5天后完全康复。使用家犬（Canis lupus familiaris）的全血对海岛灰狐进行成功的异种输血是可行的，且可能挽救其生命。
