Smith Joe S, Viall Austin K, Breuer Ryan M, Walton Rebecca A, Plummer Paul J, Griffith Ronald W, Kreuder Amanda J
Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States.
Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, United States.
Front Vet Sci. 2021 Mar 4;8:637988. doi: 10.3389/fvets.2021.637988. eCollection 2021.
Anemia requiring whole blood transfusion for appropriate treatment is a common clinical presentation of caprine patients to veterinary practitioners; however, identifying suitable blood donors in goat herds can be challenging. In other veterinary species, the practice of xenotransfusion, where blood from 1 species is transfused to another, is used in emergency settings. Due to their ability to donate large volumes of whole blood, cattle could be an ideal source for xenotransfusion of goats. In this study 2 healthy goats were transfused with bovine whole blood. The goats were then monitored for adverse effects and the presence of bovine erythrocyte post-xenotransfusion. Afterward, 15 caprine-bovine combinations were evaluated for compatibility via cross-matching. Both goats tolerated xenotransfusion, although transient reactions were observed. Of the 15 cross-match combinations, 11 of the major cross matches were compatible, and all minor cross matches were also compatible. While future work is necessary to refine this technique, xenotransfusion of goats with cattle blood may be a therapeutic modality for the treatment of caprine anemia.
需要输注全血进行适当治疗的贫血是兽医临床中山羊患者常见的临床表现；然而，在山羊群中识别合适的献血者可能具有挑战性。在其他兽医物种中，异种输血（即将一种物种的血液输给另一种物种）的做法用于紧急情况。由于牛能够捐献大量全血，牛可能是山羊异种输血的理想来源。在本研究中，给2只健康山羊输注了牛全血。然后对山羊进行不良反应监测以及异种输血后牛红细胞存在情况的监测。之后，通过交叉配血评估了15种山羊 - 牛组合的相容性。两只山羊都耐受异种输血，尽管观察到有短暂反应。在15种交叉配血组合中，11种主要交叉配血是相容的，并且所有次要交叉配血也都是相容的。虽然未来需要进一步完善这项技术，但用牛血对山羊进行异种输血可能是治疗山羊贫血的一种治疗方式。
