Institute for Respiratory Health, Centre for Respiratory Health, and Centre for Cell Therapy and Regenerative Medicine, School of Medicine and Pharmacology, University of Western Australia and Harry Perkins Institute of Medical Research, Nedlands, Western Australia, Australia.
Institute for Respiratory Health, Centre for Respiratory Health, and Centre for Cell Therapy and Regenerative Medicine, School of Medicine and Pharmacology, University of Western Australia and Harry Perkins Institute of Medical Research, Nedlands, Western Australia, Australia.
Fertil Steril. 2016 Oct;106(5):1018-1024. doi: 10.1016/j.fertnstert.2016.09.005.
The mesothelium was traditionally thought to be a simple tissue with the sole function of providing a slippery, nonadhesive, and protective surface to allow easy movement of organs within their body cavities. However, our knowledge of mesothelial cell physiology is rapidly expanding, and the mesothelium is now recognized as a dynamic cellular membrane with many other important functions. When injured, mesothelial cells initiate a cascade of processes leading either to complete regeneration of the mesothelium or the development of pathologies such as adhesions. Normal mesothelial healing is unique in that, unlike with other epithelial-like surfaces, healing appears diffusely across the denuded surface, whereas for epithelium healing occurs solely at the wound edges. This is because of a free-floating population of mesothelial cells which attach to the injured serosa. Taking advantage of this phenomenon, intraperitoneal injections of mesothelial cells have been assessed for their ability to prevent adhesion formation. This review discusses some of the functions of mesothelial cells regarding maintenance of serosal integrity and outlines the mechanisms involved in mesothelial healing. In addition, the pathogenesis of adhesion formation is discussed with particular attention to the potential role of mesothelial cells in both preventing and inducing their development.
传统上认为间皮是一种简单的组织，其唯一的功能是提供一个光滑、不粘连和保护的表面，以允许器官在体腔中轻松移动。然而，我们对间皮细胞生理学的认识正在迅速扩展，间皮现在被认为是一种具有许多其他重要功能的动态细胞膜。当受到损伤时，间皮细胞会启动一系列过程，导致间皮完全再生或发展为粘连等病理状态。正常的间皮愈合是独特的，因为与其他类似上皮的表面不同，愈合似乎是在裸露的表面上弥漫性地发生，而对于上皮，愈合仅发生在伤口边缘。这是因为有一群游离的间皮细胞附着在受伤的浆膜上。利用这一现象，已经评估了腹腔内注射间皮细胞预防粘连形成的能力。这篇综述讨论了间皮细胞在维持浆膜完整性方面的一些功能，并概述了间皮细胞愈合所涉及的机制。此外，还讨论了粘连形成的发病机制，特别关注间皮细胞在预防和诱导其发展中的潜在作用。
