Goto M, Oshima I, Tomita T, Ebihara S
Department of Animal Physiology, Faculty of Agriculture, Nagoya University, Japan.
J Pineal Res. 1989;7(2):195-204. doi: 10.1111/j.1600-079x.1989.tb00667.x.
Pineal melatonin content at several times during the day and night was measured in 36 inbred strains of mice (Mus musculus) kept under LD 12:12 cycles. The results have indicated that only five inbred strains have pineal melatonin content, with higher levels during the night and lower levels during the day; the other 31 strains do not contain detectable melatonin in their pineal gland at any of times examined. The former group includes two commonly used strains (C3H/He and CBA/Ms) and three wild-derived strains (Mol-A, Mol-Nis, MOM). C3H and CBA mice showed a similar pattern of pineal melatonin rhythm with a peak at 2 hours before lights on. The peak levels were about 150 pg/gland in both strains. The rhythmic patterns of melatonin content in Mol-A, Mol-Nis, and MOM were slightly different from those in CBA and C3H. In the wild-derived strains, the peak of melatonin content did not occur at 2 hours before lights on but tended to occur at midnight. The peak levels were 67-91 pg/gland at the highest point in these strains.
在12小时光照/12小时黑暗（LD 12:12）周期饲养的36个近交系小鼠（小家鼠）中，测定了昼夜不同时间点的松果体褪黑素含量。结果表明，只有5个近交系小鼠的松果体褪黑素含量呈现出夜间水平较高、白天水平较低的规律；在所有检测时间点，其他31个品系的小鼠松果体中均未检测到可检测到的褪黑素。前一组包括两个常用品系（C3H/He和CBA/Ms）和三个野生来源品系（Mol-A、Mol-Nis、MOM）。C3H和CBA小鼠的松果体褪黑素节律模式相似，在光照前2小时达到峰值。两个品系的峰值水平均约为150 pg/腺体。Mol-A、Mol-Nis和MOM的褪黑素含量节律模式与CBA和C3H略有不同。在野生来源品系中，褪黑素含量峰值并非出现在光照前2小时，而是倾向于出现在午夜。这些品系中最高点的峰值水平为67 - 91 pg/腺体。
