From the Department of Ophthalmology (Bompastor-Ramos, Póvoa, Lobo, Murta), Centro Hospitalar e Universitário de Coimbra, and the Faculty of Medicine (Lobo, Murta), University of Coimbra, Coimbra, Portugal; the Research and Development Department (Rodriguez, Alió), Ophthalmic Explants Biobank, Vissum Alicante, and the Division of Ophthalmology (Alió), Universidad Miguel Hernández, Alicante, Spain; the John A. Moran Eye Center (Werner), University of Utah, Salt Lake City, Utah, USA.
From the Department of Ophthalmology (Bompastor-Ramos, Póvoa, Lobo, Murta), Centro Hospitalar e Universitário de Coimbra, and the Faculty of Medicine (Lobo, Murta), University of Coimbra, Coimbra, Portugal; the Research and Development Department (Rodriguez, Alió), Ophthalmic Explants Biobank, Vissum Alicante, and the Division of Ophthalmology (Alió), Universidad Miguel Hernández, Alicante, Spain; the John A. Moran Eye Center (Werner), University of Utah, Salt Lake City, Utah, USA.
J Cataract Refract Surg. 2016 Sep;42(9):1324-1331. doi: 10.1016/j.jcrs.2016.06.032.
To report late postoperative opacification of a model of hydrophilic-hydrophobic acrylic intraocular lens (IOL) as well as the clinical consequences and laboratory characteristics.
Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Retrospective case series.
Medical records were reviewed of patients with Lentis LS-502-1 IOL opacification reporting visual loss who had IOL explantation between November 2013 and March 2015. Patients were identified in the emergency room or during regular follow-up visits. Explanted IOLs were analyzed at the Ophthalmic Explants Biobank, Vissum, Spain, or at the John A. Moran Eye Center, University of Utah, USA.
Twenty opacified IOLs were explanted from 19 patients. The mean interval between cataract surgery and diagnosis of opacification was 29.15 months ± 9.57 (SD) (range 6 to 45 months). Opacification led to a statistically significant reduction in corrected distance visual acuity (mean 0.86 ± 0.76 logMAR; P < .001) and occurred in 5.1% of the hydrophilic-hydrophobic acrylic IOLs implanted at the department. The most frequently associated medical conditions were arterial hypertension, diabetes, and glaucoma. All IOLs but 1 had a similar pattern of opacification, with yellowish diffuse opacification uniformly distributed and calcium deposits on the surface and/or subsurface of the optic and haptics and within the IOL material.
Opacification of the hydrophilic-hydrophobic acrylic IOL was found in a significant number of patients and had a significant effect on their vision. The opacification was attributed to primary calcification.
None of the authors has a financial or proprietary interest in any material or method mentioned.
报告亲水-疏水性丙烯酸型人工晶状体（IOL）模型的术后晚期混浊情况，以及其临床后果和实验室特征。
葡萄牙科英布拉中心医院眼科。
回顾性病例系列。
回顾 2013 年 11 月至 2015 年 3 月期间因 Lentis LS-502-1 IOL 混浊导致视力丧失而接受 IOL 摘除术的患者的病历。在急诊室或常规随访中发现患者。在西班牙 Vissum 眼科植入物生物银行或美国犹他大学约翰·A·莫兰眼科中心分析取出的 IOL。
从 19 名患者中取出了 20 个混浊的 IOL。白内障手术后至混浊诊断的平均间隔时间为 29.15 个月±9.57（SD）（范围 6 至 45 个月）。混浊导致校正后的距离视力明显下降（平均 0.86±0.76 logMAR；P<.001），并且在该科室植入的亲水-疏水性丙烯酸 IOL 中占 5.1%。最常伴发的疾病为动脉高血压、糖尿病和青光眼。除 1 例外，所有 IOL 均具有相似的混浊模式，表现为均匀分布的淡黄色弥漫性混浊，并在光学和柄部的表面和/或亚表面以及 IOL 材料内有钙沉积。
亲水-疏水性丙烯酸 IOL 的混浊在大量患者中发现，并对其视力有显著影响。混浊归因于原发性钙化。
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