降压药物对人工晶状体清晰度的影响。
The effect of hypotensive drugs on intraocular lenses clarity.
机构信息
Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel.
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
出版信息
Eye (Lond). 2023 Jun;37(8):1696-1703. doi: 10.1038/s41433-022-02225-w. Epub 2022 Sep 7.
OBJECTIVES
To assess the effect of hypotensive drugs on light absorbance, discoloration, opacification and precipitate formation of IOLs.
METHODS
In this laboratory study, four types of IOLs (two hydrophilic-acrylic-L1 and L2, and two hydrophobic-acrylic-B1 and B2) were soaked in solutions containing Timolol-maleate 0.5%, Dorzolamide 2%, Brimonidine-tartrate 0.2%, Latanoprost 0.005%, Brimonidine-tartrate/Timolol-maleate 0.2%/0.5% and Dorzolamide/Timolol-maleate 2%/0.5%. Non-treated IOLs and IOLs soaked in balanced salt solution (BSS) served as controls. All Treated lenses were sealed in containers and placed in an oven at 82 degrees Celsius for 120 days. Each IOL was examined using four different techniques: light microscopy imaging, light absorbance measurements at 550 nanometers through the optic's center, assessment of by a scanning electron microscope (SEM), and energy dispersive Xray spectrometry (EDX).
RESULTS
Ninety-eight IOLs were included. All BSS-soaked IOLs appeared clear with no significant discoloration or precipitate-formation. Light absorbance in these lenses was comparable to that of non-soaked, non-heated IOLs. No calcium or phosphate were detected in either of these groups. Light absorbance differed significantly between the four treated IOL types. The drops most affecting light absorbance differed between IOLs. Gross examination revealed brown and yellow discoloration of all IOLs soaked in Dorzolamide and Brimonidine-tartrate solutions, respectively. SEM demonstrated precipitates that differed in size, morphology and distribution, between different IOL-solution combinations. EDX's demonstrated the presence calcium and phosphor in the majority of precipitates and the presence of sulfur in brown discolored IOLs.
CONCLUSIONS
In vitro, interactions between hypotensive drugs and IOLs induce changes in light absorbance, discoloration and precipitate formation.
目的
评估降压药物对人工晶状体（IOL）的光吸收、变色、混浊和沉淀形成的影响。
方法
在这项实验室研究中，将四种类型的 IOL（两种亲水性丙烯酸-L1 和 L2，以及两种疏水性丙烯酸-B1 和 B2）浸泡在含有马来酸噻吗洛尔 0.5%、多佐胺 2%、酒石酸溴莫尼定 0.2%、拉坦前列素 0.005%、酒石酸溴莫尼定/马来酸噻吗洛尔 0.2%/0.5%和多佐胺/马来酸噻吗洛尔 2%/0.5%的溶液中。未处理的 IOL 和浸泡在平衡盐溶液（BSS）中的 IOL 作为对照。所有处理过的镜片都密封在容器中，并放置在 82°C 的烤箱中 120 天。使用四种不同的技术检查每个 IOL：通过光学中心的 550 纳米处的光吸收测量值、光显微镜成像、扫描电子显微镜（SEM）评估和能量色散 X 射线光谱法（EDX）。
结果
共纳入 98 个 IOL。所有浸泡在 BSS 中的 IOL 均清晰透明，无明显变色或沉淀形成。这些镜片的光吸收率与未浸泡、未加热的 IOL 相当。这些组均未检测到钙或磷酸盐。四种处理过的 IOL 类型之间的光吸收率差异显著。对光吸收率影响最大的滴剂在 IOL 之间有所不同。大体检查显示，分别浸泡在多佐胺和酒石酸溴莫尼定溶液中的所有 IOL 均发生棕色和黄色变色。SEM 显示不同 IOL-溶液组合之间沉淀的大小、形态和分布存在差异。EDX 显示大多数沉淀中存在钙和磷，棕色变色的 IOL 中存在硫。
结论
在体外，降压药物与 IOL 之间的相互作用会引起光吸收、变色和沉淀形成的变化。
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