From the Department of Ophthalmology (Scherer, Prahs, Radeck, Helbig, Märker), University Hospital Regensburg, and the Center for Clinical Studies (Müller), University Hospital Regensburg, Regensburg, Germany.
J Cataract Refract Surg. 2020 Dec;46(12):1624-1629. doi: 10.1097/j.jcrs.0000000000000342.
To identify potential risk factors related to the opacification of a hydrophilic-hydrophobic acrylic intraocular lens (IOL) model.
University Hospital Regensburg, Department of Ophthalmology, Regensburg, Germany.
Cross-sectional study.
All patients with a Lentis LS-502-1 IOL implanted at the Department of Ophthalmology were identified. Existing medical records and information from the treating ophthalmologists were reviewed to determine the IOL status (clear or opacified). Potential risk factors were analyzed using binary logistic regression models.
A total of 223 IOLs of 199 patients were included. Sixty-seven (30.0%) opacified (calcified) IOLs were identified and compared with a control group of 156 IOLs. Statistical analyses revealed age at IOL implantation (odds ratio [OR] = 1.05, P = .012) to be associated with an increased risk of calcification. Posterior capsulotomy (OR = 0.45, P = .011) was found to have a protective influence. No other ophthalmic or systemic condition showed a significant association. Mean corrected distance visual acuity diminished significantly under opacification from 0.21 ± 0.25 logarithm of the correct minimum angle of resolution (logMAR) to 0.42 ± 0.32 logMAR (P < .001). IOL exchange in 55 of 67 cases at 45.8 ± 20.5 months after initial implantation yielded significant visual recovery (P = .001).
Age at implantation might be a risk factor of IOL calcification, whereas posterior capsulotomy might be a protective factor. Calcification of the LS-502-1 IOL might be caused by the interaction of 3 main factors: IOL material traits, manufacturing-associated contamination, and patients' individual factors altering intraocular ion concentrations.
确定与亲水-疏水性丙烯酸型人工晶状体（IOL）模型混浊相关的潜在危险因素。
德国雷根斯堡大学医院眼科。
横断面研究。
确定在眼科植入 Lentis LS-502-1 IOL 的所有患者。查阅现有病历和眼科医生的信息，以确定 IOL 状态（透明或混浊）。使用二项逻辑回归模型分析潜在的危险因素。
共纳入 199 例患者的 223 枚 IOL。确定了 67 枚（30.0%）混浊（钙化）IOL，并与 156 枚 IOL 对照组进行比较。统计分析显示，IOL 植入时的年龄（优势比[OR] = 1.05，P =.012）与钙化风险增加相关。后囊切开术（OR = 0.45，P =.011）具有保护作用。没有其他眼科或全身状况显示出显著的相关性。混浊后平均矫正距离视力明显下降，从 0.21 ± 0.25 对数最小角分辨率矫正视力（logMAR）降至 0.42 ± 0.32 logMAR（P <.001）。在初始植入后 45.8 ± 20.5 个月的 55 例 67 例中进行 IOL 置换，视力显著恢复（P =.001）。
植入时的年龄可能是 IOL 钙化的危险因素，而后囊切开术可能是保护因素。LS-502-1 IOL 的钙化可能是由 3 个主要因素的相互作用引起的：IOL 材料特性、与制造相关的污染以及改变眼内离子浓度的患者个体因素。
