Shan Rong, Yin Hong, Yang Wenjuan, Li Jianzhi, Zhang Meifang, Zhao Min, Shao Jiang, Wang Aiguang
Department of Ultrasound, Jinan Infectious Disease Hospital, Jinan, Shandong 250021, P.R. China; Department of Ultrasound, Shandong University, Jinan, Shandong 250014, P.R. China.
Department of Ultrasound, Jinan Maternity and Child Care Hospital, Jinan, Shandong 250000, P.R. China.
Exp Ther Med. 2016 Oct;12(4):2302-2306. doi: 10.3892/etm.2016.3617. Epub 2016 Aug 24.
Liver stiffness, which correlates well with liver fibrosis stage, can be measured noninvasively by transient elastography, also known as Fibroscan. The present study aimed to determine the independent factors influencing Fibroscan detection by multiple regression analysis. A total of 181 patients who required liver biopsy were enrolled. Liver stiffness measurement (LSM) was detected by Fibroscan on the day of liver biopsy, while clinical information and routine biochemical examination results were also collected. Correlation was analyzed by Spearman's correlation, and multiple regression analysis was performed to analyze the independent influencing factors. The results demonstrated that platelet (PLT) levels, serum albumin (ALB), prothrombin activity (PTA) and body mass index (BMI) were independent predictors of liver stiffness. The contribution of these four predictors to the regression equation was in the following descending order: PLT (negative correlation) > ALB (negative correlation) > PTA (negative correlation) > BMI (positive correlation). In conclusion, the parameters of PLT, ALB, PTA and BMI are independent predicting factors affecting Fibroscan detection. Therefore, the diagnosis and evaluation of liver fibrosis should comprehensively consider the results of Fibroscan, and clinical and laboratory examinations.
肝脏硬度与肝纤维化分期密切相关，可通过瞬时弹性成像技术（也称为Fibroscan）进行无创测量。本研究旨在通过多元回归分析确定影响Fibroscan检测的独立因素。共纳入181例需要进行肝活检的患者。在肝活检当天通过Fibroscan检测肝脏硬度值（LSM），同时收集临床信息和常规生化检查结果。采用Spearman相关性分析，进行多元回归分析以分析独立影响因素。结果表明，血小板（PLT）水平、血清白蛋白（ALB）、凝血酶原活动度（PTA）和体重指数（BMI）是肝脏硬度的独立预测指标。这四个预测指标对回归方程的贡献按以下降序排列：PLT（负相关）>ALB（负相关）>PTA（负相关）>BMI（正相关）。总之，PLT、ALB、PTA和BMI参数是影响Fibroscan检测的独立预测因素。因此，肝纤维化的诊断和评估应综合考虑Fibroscan结果以及临床和实验室检查结果。
