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睡眠障碍与精神疾病的流行病学研究。预防的契机?

Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention?

作者信息

Ford D E, Kamerow D B

机构信息

Primary Care Research Program, National Institute of Mental Health, Rockville, Md.

出版信息

JAMA. 1989 Sep 15;262(11):1479-84. doi: 10.1001/jama.262.11.1479.

Abstract

As part of the National Institute of Mental Health Epidemiologic Catchment Area study, 7954 respondents were questioned at baseline and 1 year later about sleep complaints and psychiatric symptoms using the Diagnostic Interview Schedule. Of this community sample, 10.2% and 3.2% noted insomnia and hypersomnia, respectively, at the first interview. Forty percent of those with insomnia and 46.5% of those with hypersomnia had a psychiatric disorder compared with 16.4% of those with no sleep complaints. The risk of developing new major depression was much higher in those who had insomnia at both interviews compared with those without insomnia (odds ratio, 39.8; 95% confidence interval, 19.8 to 80.0). The risk of developing new major depression was much less for those who had insomnia that had resolved by the second visit (odds ratio, 1.6; 95% confidence interval, 0.5 to 5.3). Further research is needed to determine if early recognition and treatment of sleep disturbances can prevent future psychiatric disorders.

摘要

作为美国国立精神卫生研究所流行病学集水区研究的一部分,7954名受访者在基线时和1年后接受了询问,使用诊断访谈表了解他们的睡眠问题和精神症状。在这个社区样本中,首次访谈时分别有10.2%和3.2%的人表示存在失眠和嗜睡问题。失眠者中有40%、嗜睡者中有46.5%患有精神障碍,相比之下,无睡眠问题者中这一比例为16.4%。两次访谈均有失眠问题的人患新发重度抑郁症的风险比无失眠问题的人高得多(优势比为39.8;95%置信区间为19.8至80.0)。第二次访视时失眠问题已解决的人患新发重度抑郁症的风险要小得多(优势比为1.6;95%置信区间为0.5至5.3)。需要进一步研究以确定对睡眠障碍的早期识别和治疗是否能预防未来的精神障碍。

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