Ghajar A, Neishabouri S M, Velayati N, Jahangard L, Matinnia N, Haghighi M, Ghaleiha A, Afarideh M, Salimi S, Meysamie A, Akhondzadeh S
Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Research Center for Behavioral Disorders and Substance Abuse, Hamadan University of Medical Sciences, Hamadan, Iran.
Pharmacopsychiatry. 2017 Jul;50(4):152-160. doi: 10.1055/s-0042-116159. Epub 2016 Oct 4.
Saffron (.) has demonstrated antidepressant effects in clinical studies and extensive anxiolytic effects in experimental animal models. 66 patients with major depressive disorder accompanied by anxious distress were randomly assigned to receive either saffron (30 mg/day) or citalopram (40 mg/day) for 6 weeks. Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) were used to assess treatment effect during the trial. 60 participants finished the study. Patients who received either saffron or citalopram showed significant improvement in scores of the Hamilton Rating Scale for Depression (P-value<0.001 in both groups) and Hamilton Rating Scale for Anxiety (P-value<0.001 in both groups). Comparison of score changes between the 2 trial arms showed no significant difference (P-value=0.984). Frequency of side effects was not significantly different between the 2 groups. The present study indicates saffron as a potential efficacious and tolerable treatment for major depressive disorder with anxious distress.
藏红花（……）在临床研究中已显示出抗抑郁作用，在实验动物模型中具有广泛的抗焦虑作用。66例伴有焦虑困扰的重度抑郁症患者被随机分配接受藏红花（30毫克/天）或西酞普兰（40毫克/天）治疗6周。在试验期间，使用汉密尔顿抑郁评定量表（HAM-D）和汉密尔顿焦虑评定量表（HAM-A）评估治疗效果。60名参与者完成了研究。接受藏红花或西酞普兰治疗的患者在汉密尔顿抑郁评定量表得分（两组P值均<0.001）和汉密尔顿焦虑评定量表得分（两组P值均<0.001）上均有显著改善。两个试验组之间得分变化的比较无显著差异（P值=0.984）。两组间副作用发生率无显著差异。本研究表明，藏红花是治疗伴有焦虑困扰的重度抑郁症的一种潜在有效且耐受性良好的治疗方法。
