Buck E E, Fernhall B, Manfredi T G
J Sports Med Phys Fitness. 1989 Mar;29(1):71-6.
The purpose of the study was to investigate the separate influence of exercise and dietary intervention and their interaction on body weight, heart weight, total cholesterol, and high density lipoprotein cholesterol (HDL-C) in rats. Thirty-two male rats were randomly placed into 4 groups: normal diet-inactive (NI), normal diet-exercise (NE), cholesterol diet-inactive (CI), and cholesterol diet-exercise (CE). The exercise protocol consisted of swimming to exhaustion with a 5% gram tail weight, 5 days x wk-1 for seven weeks. Both diet and exercise had a significant effect on heart weight/body weight ratios, primarily due to changes in body weight. Neither exercise nor diet intervention produced a significant change in heart weight. The high cholesterol diet produced greater total cholesterol levels (p less than 0.05), but significantly lower HDL-C levels (p less than 0.05) than the normal diet. Exercise exhibited no independent effect on cholesterol or HDL-C concentrations, although there was a trend in a favorable direction. The data suggest that exercise cannot offset the effects of a high cholesterol diet, and that dietary treatment may play a greater role than exercise on altering serum cholesterol and HDL-C. These data imply that aggressive diet therapy should accompany exercise in the treatment of high serum cholesterol.
该研究的目的是调查运动和饮食干预及其相互作用对大鼠体重、心脏重量、总胆固醇和高密度脂蛋白胆固醇（HDL-C）的单独影响。32只雄性大鼠被随机分为4组：正常饮食-不运动（NI）、正常饮食-运动（NE）、高胆固醇饮食-不运动（CI）和高胆固醇饮食-运动（CE）。运动方案包括带着5%克的尾重游泳至力竭，每周5天，共7周。饮食和运动对心脏重量/体重比均有显著影响，主要是由于体重的变化。运动和饮食干预均未使心脏重量产生显著变化。高胆固醇饮食组的总胆固醇水平更高（p<0.05），但高密度脂蛋白胆固醇水平显著低于正常饮食组（p<0.05）。运动对胆固醇或高密度脂蛋白胆固醇浓度没有独立影响，尽管有朝着有利方向发展的趋势。数据表明运动无法抵消高胆固醇饮食的影响，并且在改变血清胆固醇和高密度脂蛋白胆固醇方面，饮食治疗可能比运动发挥更大的作用。这些数据意味着在治疗高血清胆固醇时，积极的饮食疗法应与运动相结合。
