Leeds E M, Wilkerson J E, Brown G D, Kamen G, Bredle D
Med Sci Sports Exerc. 1986 Dec;18(6):663-7.
Forty male and 40 female rats were randomly assigned to 1 of 4 experimental groups. Half of the animals of each gender were exercised by jumping (weighted by a vest with up to 70% body weight) to a height of 16 cm 20 times X d-1 (30 s between jumps) 5 d X wk-1 for 8 wk. Half of the exercised animals and half of the sedentary animals were injected with the anabolic steroid durabolin (0.2 mg in 0.1 ml sesame seed oil) 6 d X wk-1 for the last 3 wk of the 8-wk exercise program. The other animals were injected with 0.1 ml of sesame seed oil (as a placebo) on the same schedule. At the end of the 8-wk program, blood was drawn from the right atria of the anesthetized animals. Plasmas were analyzed for total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) concentrations. Low density lipoprotein cholesterol (LDL-C) concentration was estimated as the difference between these two parameters (TC - HDL-C). A three-factor analysis of variance (2 X 2 X 2) demonstrated that there was a significant (P less than 0.05) gender effect (males greater than females), but no steroid or exercise main effects for TC. There were significant (P less than 0.05) steroid and exercise main effects for both HDL-C and estimated LDL-C, as well as a significant gender main effect for estimated LDL-C (but not HDL-C).(ABSTRACT TRUNCATED AT 250 WORDS)
40只雄性和40只雌性大鼠被随机分配到4个实验组中的1组。每种性别的动物一半通过跳跃进行锻炼（穿着重达体重70%的背心），跳到16厘米的高度，每天20次，每次间隔30秒，每周5天，共8周。在为期8周的锻炼计划的最后3周，锻炼动物的一半和久坐动物的一半每周6天注射合成代谢类固醇苯丙酸诺龙（0.2毫克溶于0.1毫升芝麻油）。其他动物按相同时间表注射0.1毫升芝麻油（作为安慰剂）。在8周计划结束时，从麻醉动物的右心房取血。分析血浆中的总胆固醇（TC）和高密度脂蛋白胆固醇（HDL-C）浓度。低密度脂蛋白胆固醇（LDL-C）浓度通过这两个参数之差（TC - HDL-C）估算。三因素方差分析（2×2×2）表明，存在显著的（P＜0.05）性别效应（雄性大于雌性），但对于TC不存在类固醇或锻炼的主效应。对于HDL-C和估算的LDL-C，存在显著的（P＜0.05）类固醇和锻炼主效应，对于估算的LDL-C存在显著的性别主效应（但对于HDL-C不存在）。（摘要截断于250字）
