Pels A E, White T P, Block W D
J Appl Physiol (1985). 1985 Feb;58(2):612-8. doi: 10.1152/jappl.1985.58.2.612.
We studied the effects of exercise training on plasma lipid and lipoprotein concentrations of rats on a high-fat and high-cholesterol diet. Twelve weeks of training occurred at moderate [Mod-Exer, 70% peak O2 consumption (VO2)] and high (High-Exer, 82% peak VO2) intensities. The duration of daily training sessions was adjusted to maintain equivalent energy expenditure between groups. Following training, body weight and lean body mass were 10% lower in the High-Exer group than the Mod-Exer or control groups. Compared with control values, carcass fat content was 33% lower for both trained groups. The oxidative capacity of skeletal muscle was approximately 30% greater in the trained groups compared with the control group. Total cholesterol, high density lipoprotein cholesterol, and total triglyceride concentrations in plasma were not different between the trained groups, but were 33-47% lower compared with the control group. The exercise-induced changes in plasma lipid and lipoprotein concentrations may be a result of a change in preferred substrate utilization in skeletal muscle toward a greater oxidation of lipid.
我们研究了运动训练对高脂高胆固醇饮食大鼠血浆脂质和脂蛋白浓度的影响。训练为期12周，强度分为中等强度[中等强度运动组（Mod-Exer），峰值摄氧量（VO2）的70%]和高强度（高强度运动组（High-Exer），峰值VO2的82%）。每天训练的时长进行了调整，以保持各组间能量消耗相当。训练后，高强度运动组的体重和去脂体重比中等强度运动组或对照组低10%。与对照组相比，两个训练组的体脂含量均降低了33%。与对照组相比，训练组骨骼肌的氧化能力大约高30%。训练组之间血浆总胆固醇、高密度脂蛋白胆固醇和总甘油三酯浓度没有差异，但与对照组相比降低了33%-47%。运动引起的血浆脂质和脂蛋白浓度变化可能是由于骨骼肌中优先利用的底物向更多脂质氧化转变的结果。
