Franceschi S, Serraino D, Bidoli E, Talamini R, Tirelli U, Carbone A, La Vecchia C
Epidemiology Unit, Aviano Cancer Center, Italy.
Leuk Res. 1989;13(6):465-72. doi: 10.1016/0145-2126(89)90168-9.
We concluded a study on 208 cases of non-Hodgkin's lymphoma and 401 controls in the North-East of Italy in order to investigate the role of indicators of socio-economic status, personal habits, past history of various disorders and medical treatments potentially affecting the immune system, and occupational exposures in the aetiology of such neoplasia. None of the several investigated characteristics appeared to be a strong determinant, i.e. relative risk, RR greater than 2.0, of non-Hodgkin's lymphoma. Cases and controls appeared to be very similar as regards education, main life-time occupation and alcohol consumption. Positive associations, however, emerged with chronic infectious diseases, mainly tuberculosis and malaria (RR = 1.8, 95% confidence interval, CI: 1.1-2.9). Non significantly increased risks were also found for smoking habit (RR ever vs never smokers = 1.5, 95% CI: 1.0-2.3), episodes of herpes zoster infection (RR = 1.4; 95% CI: 0.7-2.6) and occupation in chemical and petrochemical industries (RR = 1.6; 95% CI: 0.9-3.1, and 1.8; 95% CI: 0.9-3.8, respectively). Conversely, farming as well as specific exposure to herbicides and pesticides did not seem to affect the risk of non-Hodgkin's lymphoma in the present investigation.
我们在意大利东北部对208例非霍奇金淋巴瘤患者和401名对照者进行了一项研究，以调查社会经济地位指标、个人习惯、各种疾病的既往史以及可能影响免疫系统的医学治疗方法，还有职业暴露在这种肿瘤病因学中的作用。在几个被调查的特征中，没有一个似乎是导致非霍奇金淋巴瘤的强决定因素，即相对风险（RR）大于2.0。在教育程度、主要终身职业和饮酒方面，病例组和对照组似乎非常相似。然而，与慢性传染病（主要是结核病和疟疾，RR = 1.8，95%置信区间，CI：1.1 - 2.9）出现了正相关。吸烟习惯（曾经吸烟者与从不吸烟者的RR = 1.5，95% CI：1.0 - 2.3）、带状疱疹感染发作（RR = 1.4；95% CI：0.7 - 2.6）以及在化学和石油化工行业的职业暴露（RR分别为1.6；95% CI：0.9 - 3.1和1.8；95% CI：0.9 - 3.8）也发现风险有非显著性增加。相反，在本研究中，务农以及接触除草剂和杀虫剂似乎并未影响非霍奇金淋巴瘤的发病风险。
