La Vecchia C, Negri E, D'Avanzo B, Franceschi S
Mario Negri Institute for Pharmacological Research, Milan, Italy.
Br J Cancer. 1989 Sep;60(3):385-8. doi: 10.1038/bjc.1989.290.
The relationship between occupation and exposure to a number of occupational agents and lymphoid neoplasms was investigated in a case-control study of 69 cases of Hodgkin's disease, 153 non-Hodgkin's lymphomas, 110 multiple myelomas and 396 controls admitted for acute diseases to a network of teaching and general hospitals in the greater Milan area. Among the cases, there was a significant excess of individuals ever occupied in agriculture and food processing: the multivariate relative risks (RR) were 2.1 (95% confidence interval, CI = 1.0-3.8) for Hodgkin's disease, 1.9 (95% CI = 1.2-3.0) for non-Hodgkin's lymphomas and 2.0 (95% CI = 1.1-3.5) for multiple myeloma. Significant trends for duration of exposure to herbicides were observed for lymphomas, but the association was stronger for overall occupation in agriculture than with the specific question of herbicide use. History of occupation in the chemical industry was more frequent among Hodgkin's disease (RR = 4.3, 95% CI = 1.4-10.2), and a significant trend in risk was observed between duration of exposure to benzene and other solvents and multiple myeloma. No significant relation was found between any of the lymphoid neoplasms considered and rubber, dye, painting, printing, tanning leather, photography, pharmaceuticals, wood, coal/gas and nuclear industries.
在一项病例对照研究中，调查了大米兰地区教学医院和综合医院网络收治的69例霍奇金病、153例非霍奇金淋巴瘤、110例多发性骨髓瘤患者及396例急性病对照患者的职业与多种职业性接触因素和淋巴系统肿瘤之间的关系。在病例组中，从事农业和食品加工的人数显著过多：霍奇金病的多变量相对风险（RR）为2.1（95%置信区间，CI = 1.0 - 3.8），非霍奇金淋巴瘤为1.9（95% CI = 1.2 - 3.0），多发性骨髓瘤为2.0（95% CI = 1.1 - 3.5）。观察到淋巴瘤患者接触除草剂的时间存在显著趋势，但农业总体职业的关联比除草剂使用的具体问题更强。化学工业的职业史在霍奇金病患者中更为常见（RR = 4.3，95% CI = 1.4 - 10.2），并且观察到接触苯和其他溶剂的时间与多发性骨髓瘤之间存在显著的风险趋势。在所考虑的任何淋巴系统肿瘤与橡胶、染料、油漆、印刷、制革、摄影、制药、木材、煤炭/天然气和核工业之间均未发现显著关系。
