Bucholz Emily M, Butala Neel M, Ma Shuangge, Normand Sharon-Lise T, Krumholz Harlan M
From the Department of Medicine, Boston Children's Hospital (E.M.B.), the Department of Internal Medicine, Massachusetts General Hospital (N.M.B.), the Department of Health Care Policy, Harvard Medical School (S.-L.T.N.), and the Department of Biostatistics, Harvard T.H. Chan School of Public Health (S.-L.T.N.) - all in Boston; and the Departments of Biostatistics (S.M.) and Health Policy and Management (H.M.K.), Yale School of Public Health, the Section of Cardiovascular Medicine, Department of Internal Medicine, and Robert Wood Johnson Clinical Scholars Program, Yale School of Medicine (H.M.K.), and Center for Outcomes Research and Evaluation, Yale-New Haven Hospital (H.M.K.) - all in New Haven, CT.
N Engl J Med. 2016 Oct 6;375(14):1332-1342. doi: 10.1056/NEJMoa1513223.
Thirty-day risk-standardized mortality rates after acute myocardial infarction are commonly used to evaluate and compare hospital performance. However, it is not known whether differences among hospitals in the early survival of patients with acute myocardial infarction are associated with differences in long-term survival.
We analyzed data from the Cooperative Cardiovascular Project, a study of Medicare beneficiaries who were hospitalized for acute myocardial infarction between 1994 and 1996 and who had 17 years of follow-up. We grouped hospitals into five strata that were based on case-mix severity. Within each case-mix stratum, we compared life expectancy among patients admitted to high-performing hospitals with life expectancy among patients admitted to low-performing hospitals. Hospital performance was defined by quintiles of 30-day risk-standardized mortality rates. Cox proportional-hazards models were used to calculate life expectancy.
The study sample included 119,735 patients with acute myocardial infarction who were admitted to 1824 hospitals. Within each case-mix stratum, survival curves of the patients admitted to hospitals in each risk-standardized mortality rate quintile separated within the first 30 days and then remained parallel over 17 years of follow-up. Estimated life expectancy declined as hospital risk-standardized mortality rate quintile increased. On average, patients treated at high-performing hospitals lived between 0.74 and 1.14 years longer, depending on hospital case mix, than patients treated at low-performing hospitals. When 30-day survivors were examined separately, there was no significant difference in unadjusted or adjusted life expectancy across hospital risk-standardized mortality rate quintiles.
In this study, patients admitted to high-performing hospitals after acute myocardial infarction had longer life expectancies than patients treated in low-performing hospitals. This survival benefit occurred in the first 30 days and persisted over the long term. (Funded by the National Heart, Lung, and Blood Institute and the National Institute of General Medical Sciences Medical Scientist Training Program.).
急性心肌梗死后30天风险标准化死亡率常用于评估和比较医院绩效。然而,急性心肌梗死患者早期生存率在医院间的差异是否与长期生存率差异相关尚不清楚。
我们分析了合作心血管项目的数据,该项目研究了1994年至1996年因急性心肌梗死住院且有17年随访期的医疗保险受益人。我们根据病例组合严重程度将医院分为五个层次。在每个病例组合层次内,我们比较了入住高绩效医院患者的预期寿命与入住低绩效医院患者的预期寿命。医院绩效由30天风险标准化死亡率的五分位数定义。使用Cox比例风险模型计算预期寿命。
研究样本包括119735例急性心肌梗死患者,他们入住了1824家医院。在每个病例组合层次内,各风险标准化死亡率五分位数医院的患者生存曲线在最初30天内分开,然后在17年随访期内保持平行。估计预期寿命随着医院风险标准化死亡率五分位数的增加而下降。平均而言,根据医院病例组合,在高绩效医院接受治疗的患者比在低绩效医院接受治疗的患者寿命长0.74至1.14年。当单独检查30天幸存者时,各医院风险标准化死亡率五分位数的未调整或调整后预期寿命没有显著差异。
在本研究中,急性心肌梗死后入住高绩效医院的患者比在低绩效医院接受治疗的患者预期寿命更长。这种生存益处出现在最初30天,并长期持续。(由国家心肺血液研究所和国家普通医学科学研究所医学科学家培训项目资助。)