Shimizu Yuji, Sato Shimpei, Koyamatsu Jun, Yamanashi Hirotomo, Nagayoshi Mako, Kadota Koichiro, Maeda Takahiro
Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
Department of Cardiovascular Disease Prevention, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
Aging (Albany NY). 2016 Oct 4;8(10):2407-2413. doi: 10.18632/aging.101061.
Previously, we reported that height is an indicator of the capacity of vascular repair in elderly men, especially hypertensive men. On the other hand, hemoglobin could act as a possible biochemical index of hypertension-induced vascular damage. However, no studies have clarified the correlation between height and hematopoietic activity. We conducted a cross-sectional study of 249 men aged 65-69 undergoing a general health check-up. Reticulocyte was used to evaluate hematopoietic activity. Because hemoglobin concentration should influence hematopoietic activity, analyses stratified by hemoglobin level were performed. Independent of known cardiovascular risk factors and other hematological parameters (white blood cell count), a significant positive correlation was seen between height and reticulocytes for total subjects and subjects with a high hemoglobin concentration (≥14.5 g/dL), but not in subjects with a low hemoglobin concentration (<14.5 g/dL). The standardized parameter estimates (β) were β=0.18, p=0.003 for total subjects, β=0.28, p=0.001 for subjects with a high hemoglobin concentration, and β=0.03, p=0.717 for subjects with low hemoglobin. Independently, height is significantly positively correlated with reticulocyte in elderly Japanese men, particularly in men with a high hemoglobin concentration. These results indicate that subjects with a short stature might have lower hematopoietic capacity than those with a high stature.
此前，我们报道称身高是老年男性，尤其是老年高血压男性血管修复能力的一个指标。另一方面，血红蛋白可能是高血压所致血管损伤的一个潜在生化指标。然而，尚无研究阐明身高与造血活性之间的相关性。我们对249名65 - 69岁接受常规健康检查的男性进行了一项横断面研究。采用网织红细胞来评估造血活性。由于血红蛋白浓度会影响造血活性，因此我们按血红蛋白水平进行了分层分析。在不考虑已知心血管危险因素和其他血液学参数（白细胞计数）的情况下，在所有受试者以及血红蛋白浓度高（≥14.5 g/dL）的受试者中，身高与网织红细胞之间存在显著正相关，但在血红蛋白浓度低（<14.5 g/dL）的受试者中未发现这种相关性。标准化参数估计值（β）在所有受试者中为β = 0.18，p = 0.003；在血红蛋白浓度高的受试者中为β = 0.28，p = 0.001；在血红蛋白浓度低的受试者中为β = 0.03，p = 0.717。独立来看，在老年日本男性中，身高与网织红细胞显著正相关，尤其是在血红蛋白浓度高的男性中。这些结果表明，身材矮小的受试者可能比身材高大的受试者造血能力更低。
