Landeg Steven J, Kirby Anna M, Lee Steven F, Bartlett Freddie, Titmarsh Kumud, Donovan Ellen, Griffin Clare L, Gothard Lone, Locke Imogen, McNair Helen A
1 The Royal Marsden NHS Foundation Trust, London, UK.
2 Institute of Cancer Research (ICR), London, UK.
Br J Radiol. 2016 Dec;89(1068):20160288. doi: 10.1259/bjr.20160288. Epub 2016 Oct 6.
The purpose of this UK study was to evaluate interfraction reproducibility and body image score when using ultraviolet (UV) tattoos (not visible in ambient lighting) for external references during breast/chest wall radiotherapy and compare with conventional dark ink.
In this non-blinded, single-centre, parallel group, randomized control trial, patients were allocated to receive either conventional dark ink or UV ink tattoos using computer-generated random blocks. Participant assignment was not masked. Systematic (∑) and random (σ) setup errors were determined using electronic portal images. Body image questionnaires were completed at pre-treatment, 1 month and 6 months to determine the impact of tattoo type on body image. The primary end point was to determine that UV tattoo random error (σ) was no less accurate than with conventional dark ink tattoos, i.e. <2.8 mm.
46 patients were randomized to receive conventional dark or UV ink tattoos. 45 patients completed treatment (UV: n = 23, dark: n = 22). σ for the UV tattoo group was <2.8 mm in the u and v directions (p = 0.001 and p = 0.009, respectively). A larger proportion of patients reported improvement in body image score in the UV tattoo group compared with the dark ink group at 1 month [56% (13/23) vs 14% (3/22), respectively] and 6 months [52% (11/21) vs 38% (8/21), respectively].
UV tattoos were associated with interfraction setup reproducibility comparable with conventional dark ink. Patients reported a more favourable change in body image score up to 6 months following treatment. Advances in knowledge: This study is the first to evaluate UV tattoo external references in a randomized control trial.
这项英国研究的目的是评估在乳房/胸壁放疗期间使用紫外线（UV）纹身（在环境光下不可见）作为外部参考时的分次间重复性和身体形象评分，并与传统的深色墨水纹身进行比较。
在这项非盲法、单中心、平行组随机对照试验中，使用计算机生成的随机区组将患者分配接受传统深色墨水或UV墨水纹身。参与者的分配未设盲。使用电子门静脉图像确定系统（∑）和随机（σ）设置误差。在治疗前、1个月和6个月完成身体形象问卷，以确定纹身类型对身体形象的影响。主要终点是确定UV纹身的随机误差（σ）与传统深色墨水纹身相比不差，即<2.8毫米。
46例患者被随机分配接受传统深色或UV墨水纹身。45例患者完成治疗（UV组：n = 23，深色组：n = 22）。UV纹身组在u和v方向上的σ均<2.8毫米（分别为p = 0.001和p = 0.009）。与深色墨水组相比，UV纹身组在1个月时[分别为56%（13/23）对14%（3/22）]和6个月时[分别为52%（11/21）对38%（8/21）]有更大比例的患者报告身体形象评分有所改善。
UV纹身与传统深色墨水纹身的分次间设置重复性相当。患者报告在治疗后长达6个月的时间里身体形象评分有更有利的变化。知识进展：本研究是首次在随机对照试验中评估UV纹身外部参考。
