Zhou Jun, Liao Yuan, Xie Haitao, Liao Ying, Zeng Yahua, Li Neng, Sun Guanghua, Wu Qi, Zhou Guijuan
Department of Rehabilitation, First Affiliated Hospital of University of South China, Hengyang, People's Republic of China.
Clinical Medical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
Bioelectromagnetics. 2017 Jan;38(1):31-40. doi: 10.1002/bem.22012. Epub 2016 Oct 6.
Ibandronate (IBN) and pulsed electromagnetic field (PEMF) have each shown positive effects for treating osteoporosis, but no study has evaluated the relative effects of these treatments combined. This study investigated the effects of IBN + PEMF on bone turnover, mineral density, microarchitecture, and biomechanical properties in an ovariectomized (OVX) rat model of osteoporosis. Fifty 3-month-old rats were randomly apportioned to receive a sham-operation (n = 10), or ovariectomy (n = 40). The latter group was equally divided as the model (OVX control) or to receive IBN, PEMF, or IBN + PEMF. Beginning the day after surgery, the IBN and IBN + PEMF groups received weekly subcutaneous IBN; the PEMF and IBN + PEMF groups were given daily PEMF during the same 12 weeks. After 12 weeks of treatments, biochemical parameters, bone mineral density (BMD), microarchitecture parameters, biomechanical properties, and some metabolic modulators that are involved in bone resorption were compared. The L5 lumbar vertebral body BMDs of the IBN, PEMF, and IBN + PEMF groups were 121.6%, 119.5%, and 139.6%; maximum loads were 111.4%, 112.7%, and 121.9%; and energy to failure was 130.8%, 129.2%, and 154.9% of the OVX model, respectively. The IBN + PEMF group had significantly lower levels of serum tartrate-resistant acid phosphatase 5b, and greater improvement in BMD, bone microarchitecture, and strength of the lumbar spine compared with monotherapy groups. Results showed that IBN + PEMF had a more favorable effect on the lumbar spine in this osteoporosis model than did either monotherapy. Bioelectromagnetics. 38:31-40, 2017. © 2016 Wiley Periodicals, Inc.
伊班膦酸盐（IBN）和脉冲电磁场（PEMF）各自已显示出治疗骨质疏松症的积极效果，但尚无研究评估这些治疗联合使用的相对效果。本研究在去卵巢（OVX）大鼠骨质疏松模型中，研究了IBN + PEMF对骨转换、矿物质密度、微结构和生物力学性能的影响。将50只3个月大的大鼠随机分配接受假手术（n = 10）或去卵巢手术（n = 40）。后一组被平均分为模型组（OVX对照组）或接受IBN、PEMF或IBN + PEMF治疗。从手术后第二天开始，IBN组和IBN + PEMF组每周皮下注射IBN；PEMF组和IBN + PEMF组在相同的12周内每天接受PEMF治疗。治疗12周后，比较了生化参数、骨矿物质密度（BMD）、微结构参数、生物力学性能以及一些参与骨吸收的代谢调节因子。IBN组、PEMF组和IBN + PEMF组的L5腰椎椎体BMD分别为OVX模型组的121.6%、119.5%和139.6%；最大负荷分别为111.4%、112.7%和121.9%；破坏能量分别为130.8%、129.2%和154.9%。与单一疗法组相比，IBN + PEMF组血清抗酒石酸酸性磷酸酶5b水平显著降低，腰椎BMD、骨微结构和强度改善更大。结果表明，在该骨质疏松模型中，IBN + PEMF对腰椎的影响比单一疗法更有利。《生物电磁学》。38:31 - 40，2017年。©2016威利期刊公司。
