Eltejaei Iman, Balavand Mohsen, Mojra Afsaneh
Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran.
Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran.
Comput Methods Programs Biomed. 2021 Feb;199:105905. doi: 10.1016/j.cmpb.2020.105905. Epub 2020 Dec 18.
The thermal therapy is a minimally invasive technique used as an alternative approach to conventional cancer treatments. There is an increasing concern about the accuracy of the thermal simulation during the process of tumor ablation. This study is aimed at investigating the effect of finite speed of heat propagation in the biological lung tissue, experimentally and numerically.
In the experimental study, a boundary heat flux is applied to the lung tissue specimens and the temperature variation is measured during a transient heat transfer procedure. In the numerical study, a code is developed based on the finite volume method to solve the classical bio-heat transfer, the Cattaneo and Vernotte, and the Dual-phase-lag (DPL) equations. The thermal response of tissue during the experiments is compared with the predictions of the three heat transfer models.
It is found that the trend of temperature variation by the DPL model resembles the experimental results. The experimental observation in parallel with the numerical results reveals that the accumulated thermal energy diffuses to the surrounding tissue with a slower rate in comparison with the conventional bio-heat transfer model. The DPL model is implemented to study the temperature elevation in the laser irradiation to lung tissue in the presence of gold nanoparticles (GNPs). It is concluded that the extent of the necrotic tumoral region and the area of the damaged healthy tissue are reduced, when the non-Fourier heat transfer is taken into account.
Results show that considering the phase lags is crucial in planning for an effective thermal treatment, in which the cancerous tissue is ablated and the surrounding tissues are preserved from irreversible thermal damage.
热疗法是一种微创技术，可作为传统癌症治疗的替代方法。在肿瘤消融过程中，人们越来越关注热模拟的准确性。本研究旨在通过实验和数值方法研究生物肺组织中有限热传播速度的影响。
在实验研究中，对肺组织标本施加边界热通量，并在瞬态传热过程中测量温度变化。在数值研究中，基于有限体积法开发了一个代码，用于求解经典生物传热方程、卡塔尼奥和韦尔诺特方程以及双相滞后（DPL）方程。将实验过程中组织的热响应与三种传热模型的预测结果进行比较。
发现DPL模型的温度变化趋势与实验结果相似。与数值结果并行的实验观察表明，与传统生物传热模型相比，累积的热能以较慢的速率扩散到周围组织。利用DPL模型研究了在存在金纳米颗粒（GNP）的情况下激光照射肺组织时的温度升高情况。得出结论，当考虑非傅里叶热传递时，可以减少坏死肿瘤区域的范围和受损健康组织的面积。
结果表明，在规划有效的热治疗时考虑相位滞后至关重要，在热治疗中，癌组织被消融，周围组织免受不可逆的热损伤。
