热疗过程中生物层球形活组织中非傅里叶热传导的数值研究。
Numerical study of non-Fourier heat conduction in a biolayer spherical living tissue during hyperthermia.
作者信息
Mohajer Maedeh, Ayani Mohammad B, Tabrizi Hassan Basirat
机构信息
(a)Department of Mechanical Engineering, Faculty of Engineering, Ferdowsi University of Mashhad, P.O. Box 91775-1111, Mashhad, Iran.
(a)Department of Mechanical Engineering, Faculty of Engineering, Ferdowsi University of Mashhad, P.O. Box 91775-1111, Mashhad, Iran.
出版信息
J Therm Biol. 2016 Dec;62(Pt B):181-188. doi: 10.1016/j.jtherbio.2016.06.019. Epub 2016 Jul 2.
Laser interstitial thermal therapy is one of the best methods for tumor treatment. Quality of treatment is highly influenced by the way of temperature control that depends strongly upon the living tissue thermal properties. One-dimensional dual-phase-lag (DPL) in spherical coordinate system numerically has been investigated for bioheat transfer during laser treatment in living biological tissues, which contain tumoral and normal layers. Various behaviors of heat transfer models such as wave, wavelike and diffusion are studied by adjusting the relaxation parameters. Effect of different phase lags values of the heat flux and the temperature gradient and thermal diffusivity on the behavior of heat transfer overshooting phenomenon is also investigated as well. Results indicate variation of the time lag and the thermal diffusivity of the normal and tumoral tissues. Also it has cleared that the geometrical conditions have significant effects upon the thermal response and overshooting phenomenon in biological tissue.
激光间质热疗法是肿瘤治疗的最佳方法之一。治疗质量受温度控制方式的影响很大,而温度控制方式很大程度上取决于活体组织的热特性。在包含肿瘤层和正常层的活体生物组织中进行激光治疗期间,对球坐标系中的一维双相滞后(DPL)生物热传递进行了数值研究。通过调整松弛参数,研究了热传递模型的各种行为,如波动、波状和扩散。还研究了热通量和温度梯度的不同相位滞后值以及热扩散率对热传递过冲现象行为的影响。结果表明正常组织和肿瘤组织的时间滞后和热扩散率存在差异。此外,已经明确几何条件对生物组织中的热响应和过冲现象有显著影响。