Isolation and characterization of new secondary metabolites from .

Phytochemical study of the ethanolic extract of Salzm. et Viv. (Asphodelaceae) resulted in the isolation of two new compounds, methyl-1,4,5-trihydroxy-7-methyl-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate (), and (1) 3,10-dimethoxy-5-methyl-1-1,4-epoxybenzo[]isochromene () as well as three known compounds; 3,4-dihydroxy-methyl benzoate (), 3,4-dihydroxybenzoic acid (), and 6-methoxychrysophanol (). Compound showed a potent activity against methicillin-resistant (MRSA) and with IC values of 1.5 and 1.2 µg/mL, respectively. Compound showed antileishmanial activity with an IC value of 33.2 µg/mL. Compound is the first isochromene possessing a highly strained 1,4-epoxy moiety. The structure elucidation of isolated metabolites was carried out using spectroscopic data, the absolute configuration of based on optical rotation and electronic circular dichroism experiments and calculations.