Fruzzetti Franca, Perini Daria, Fornaciari Lara, Russo Marinella, Bucci Fiorella, Gadducci Angiolo
a Department of Obstetrics and Gynaecology , Santa Chiara Hospital , Pisa , Italy.
Eur J Contracept Reprod Health Care. 2016 Dec;21(6):449-454. doi: 10.1080/13625187.2016.1234598. Epub 2016 Oct 7.
The aim of the study was to examine, in a sample of Italian women, the rate of discontinuation of use of hormonal contraception.
In a retrospective cross-sectional study, data were collected from a chart review of 1809 women using or stopping the hormonal contraceptive prescribed by their physician. The name of the contraceptive and the reason for discontinuation were taken from the charts. The differences between the methods regarding reasons for discontinuation were analysed.
Of the 1809 women examined, 34.9% had discontinued their hormonal contraception: 6.9% did so for non-method-related reasons, 20.5% due to minor side effects, 4.4% due to major side effects and 3.8% due to difficulties with compliance. Irregular bleeding, weight gain and headache were the main reasons reported for discontinuation. Pills containing 30 μg or 20 μg ethinylestradiol (EE) and the vaginal ring were the most used contraceptive methods. Women using the vaginal ring discontinued less frequently compared with pill users (p < .005). Pills containing 20 μg and 30 μg EE had the same discontinuation rate. Venous thrombosis was the most frequently reported major side effect leading to discontinuation.
About one-third of women who used modern hormonal contraceptives discontinued the method. Although the percentage of women who gave up as a result of minor side effects was lower than it used to be, and the use of low doses of EE by the vaginal route has decreased the rate of discontinuation, physicians should counsel women about the possibility of side effects and encourage them to seek advice before stopping.
本研究旨在调查意大利女性样本中激素避孕法的停用率。
在一项回顾性横断面研究中，通过查阅1809名正在使用或停用医生所开激素避孕药的女性的病历收集数据。避孕药名称及停用原因均取自病历。分析了不同避孕方法在停用原因方面的差异。
在接受检查的1809名女性中，34.9%停用了激素避孕法：6.9%因与方法无关的原因停用，20.5%因轻微副作用停用，4.4%因严重副作用停用，3.8%因依从性困难停用。不规则出血、体重增加和头痛是报告的停用主要原因。含30μg或20μg炔雌醇（EE）的避孕药丸和阴道环是最常用的避孕方法。与使用避孕药丸的女性相比，使用阴道环的女性停用频率较低（p<0.005）。含20μg和30μg EE的避孕药丸停用率相同。静脉血栓形成是导致停用的最常报告的严重副作用。
约三分之一使用现代激素避孕法的女性停用了该方法。尽管因轻微副作用而放弃的女性比例低于过去，且经阴道途径使用低剂量EE降低了停用率，但医生应向女性咨询副作用的可能性，并鼓励她们在停药前寻求建议。
