Håkansson Krister, Ledreux Aurélie, Daffner Kirk, Terjestam Yvonne, Bergman Patrick, Carlsson Roger, Kivipelto Miia, Winblad Bengt, Granholm Ann-Charlotte, Mohammed Abdul Kadir H
Department of Psychology, Linnaeus University, Växjö, Sweden.
Center for Alzheimer Research, Division of Neurogeriatrics, Department of NVS, Karolinska Institutet, Stockholm, Sweden.
J Alzheimers Dis. 2017;55(2):645-657. doi: 10.3233/JAD-160593.
Brain-derived neurotrophic factor (BDNF) has a central role in brain plasticity by mediating changes in cortical thickness and synaptic density in response to physical activity and environmental enrichment. Previous studies suggest that physical exercise can augment BDNF levels, both in serum and the brain, but no other study has examined how different types of activities compare with physical exercise in their ability to affect BDNF levels. By using a balanced cross over experimental design, we exposed nineteen healthy older adults to 35-minute sessions of physical exercise, cognitive training, and mindfulness practice, and compared the resulting changes in mature BDNF levels between the three activities. We show that a single bout of physical exercise has significantly larger impact on serum BDNF levels than either cognitive training or mindfulness practice in the same persons. This is the first study on immediate BDNF effects of physical activity in older healthy humans and also the first study to demonstrate an association between serum BDNF responsivity to acute physical exercise and working memory function. We conclude that the BDNF increase we found after physical exercise more probably has a peripheral than a central origin, but that the association between post-intervention BDNF levels and cognitive function could have implications for BDNF responsivity in serum as a potential marker of cognitive health.
脑源性神经营养因子（BDNF）通过介导皮质厚度和突触密度的变化来响应身体活动和环境富集，在大脑可塑性中发挥核心作用。先前的研究表明，体育锻炼可以提高血清和大脑中的BDNF水平，但没有其他研究探讨过不同类型的活动在影响BDNF水平的能力方面与体育锻炼相比如何。通过使用平衡交叉实验设计，我们让19名健康的老年人分别进行35分钟的体育锻炼、认知训练和正念练习，并比较了这三种活动后成熟BDNF水平的变化。我们发现，在同一人群中，单次体育锻炼对血清BDNF水平的影响明显大于认知训练或正念练习。这是第一项关于体育活动对健康老年人BDNF即时影响的研究，也是第一项证明血清BDNF对急性体育锻炼的反应性与工作记忆功能之间存在关联的研究。我们得出结论，我们在体育锻炼后发现的BDNF增加更可能源于外周而非中枢，但干预后BDNF水平与认知功能之间的关联可能对血清BDNF反应性作为认知健康的潜在标志物具有启示意义。
