骨矿物质密度与女性左心室舒张功能相关。
Bone mineral density is associated with left ventricular diastolic function in women.
作者信息
Wang Rui-Tao, Li Xue-Song, Zhang Ji-Rong, Sun Yuxiang, Yu Kai-Jiang, Liu Tiemin
机构信息
Department of Internal Medicine, Third Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
Department of Orthopedics, First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
出版信息
Clin Cardiol. 2016 Dec;39(12):709-714. doi: 10.1002/clc.22592. Epub 2016 Oct 7.
BACKGROUND
Low bone mineral density (BMD) and left ventricular (LV) diastolic function are associated with heart failure. However, little is known about the association between BMD and LV diastolic function.
HYPOTHESIS
BMD is independently related to LV diastolic function in women.
METHODS
We conducted a cross-sectional study of 432 women. Brachial-ankle pulse wave velocity (baPWV) and BMD measurements were performed. LV diastolic function and structure were assessed by echocardiographic examination.
RESULTS
BaPWV and the percentage of LV diastolic dysfunction increased with progressive bone loss. Moreover, partial correlation analysis demonstrated that BMD at spine L2-4 and at femoral neck were correlated with baPWV and LV diastolic function parameters after adjusting covariates. Multivariate logistic regression analysis revealed that osteoporosis was independently associated with LV diastolic dysfunction in women.
CONCLUSIONS
Osteoporosis is independently associated with LV diastolic dysfunction in women. A prospective study is needed to elucidate the effects of BMD on cardiac function in women.
背景
低骨矿物质密度（BMD）与左心室（LV）舒张功能均与心力衰竭相关。然而，关于BMD与LV舒张功能之间的关联却知之甚少。
假设
BMD与女性LV舒张功能独立相关。
方法
我们对432名女性进行了一项横断面研究。测量了肱踝脉搏波速度（baPWV）和BMD。通过超声心动图检查评估LV舒张功能和结构。
结果
随着骨质流失的加重，baPWV和LV舒张功能障碍的百分比增加。此外，偏相关分析表明，在调整协变量后，L2-4椎体和股骨颈处的BMD与baPWV和LV舒张功能参数相关。多因素逻辑回归分析显示，骨质疏松症与女性LV舒张功能障碍独立相关。
结论
骨质疏松症与女性LV舒张功能障碍独立相关。需要进行前瞻性研究以阐明BMD对女性心脏功能的影响。
Zotero 插件