催化酯和酰胺到胺的转化：通过 C-O 和 C-C 键活化的镍催化酯和酰胺的脱羰基氨化反应。
Catalytic Ester and Amide to Amine Interconversion: Nickel-Catalyzed Decarbonylative Amination of Esters and Amides by C-O and C-C Bond Activation.
机构信息
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
King Abdullah University of Science and Technology (KAUST), KAUST Catalysis Center (KCC), Thuwal, 23955-6900, Saudi Arabia.
出版信息
Angew Chem Int Ed Engl. 2017 Apr 3;56(15):4282-4285. doi: 10.1002/anie.201611819. Epub 2017 Mar 15.
PMID:28294473
Abstract
An efficient nickel-catalyzed decarbonylative amination reaction of aryl and heteroaryl esters has been achieved for the first time. The new amination protocol allows the direct interconversion of esters and amides into the corresponding amines and represents a good alternative to classical rearrangements as well as cross coupling reactions.
摘要
首次实现了高效的镍催化芳基和杂芳基酯的脱羰基胺化反应。该新的胺化方案允许酯和酰胺直接相互转化为相应的胺，是经典重排以及交叉偶联反应的良好替代方法。
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