Nonlinear model predictive control applied to the separation of praziquantel in simulated moving bed chromatography.

An adaptive nonlinear model predictive control of a simulated moving bed unit for the enantioseparation of praziquantel is presented. A first principle model was applied at the proposed purity control scheme. The main concern about this kind of model in a control framework is in regard to the computational effort to solve it; however, a fast enough solution was achieved. In order to evaluate the controller's performance, several cases were simulated, including external pumps and switching valve malfunctions. The problem of plant-model mismatch was also investigated, and for that reason a parameter estimation step was introduced in the control strategy. In every studied scenario, the controller was able to maintain the purity levels at their set points, which were set to 99% and 98.6% for extract and raffinate, respectively. Additionally, fast responses and smooth actuation were achieved.