Beckert Angela K, Huisingh-Scheetz Megan, Thompson Katherine, Celauro Amy D, Williams Jordan, Pachwicewicz Paul, Ferguson Mark K
Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Department of Medicine, The University of Chicago Medicine, Chicago, Illinois.
Ann Thorac Surg. 2017 Mar;103(3):956-961. doi: 10.1016/j.athoracsur.2016.08.078. Epub 2016 Oct 6.
The presence of frailty or prefrailty in older adults is a risk factor for postsurgical complications. The frailty phenotype can be improved through long-term resistance and aerobic training. It is unknown whether short-term preoperative interventions targeting frailty will help to mitigate surgical risk. The purpose of this study was to determine the proportion of frail and prefrail patients presenting to a thoracic surgical clinic who could benefit from a frailty reduction intervention.
A prospective cohort study was performed at a single-site thoracic surgical clinic. Starting October 1, 2014, surgical candidates 60 years of age or older who consented to be screened were included. Patients were screened using an adapted version of Fried's phenotypic frailty criteria: weakness (grip strength), slow gait (15-foot walk), unintentional weight loss, self-reported exhaustion, and low self-reported physical activity (Physical Activity Scale for the Elderly). Prefrailty was identified when participants demonstrated one to two frailty characteristics; frailty was identified when participants demonstrated three to five frailty characteristics.
Of 180 eligible patients, 126 consented, and 125 completed screening. Thirty-nine participants (31%) were not frail, 71 (57%) were prefrail, and 15 (12%) were frail. Exhaustion was the most common frailty symptom (34%). Frailty prevalence did not significantly differ among men and women (men: 10%, women: 14%; p = 0.75).
We found a high proportion of prefrail and frail patients among patients deemed candidates for thoracic surgical procedures. This finding indicates that frailty may be underrecognized. Substantial numbers of patients may be considered for a presurgical frailty reduction intervention.
老年人存在衰弱或衰弱前期是术后并发症的危险因素。衰弱表型可通过长期抗阻训练和有氧运动得到改善。针对衰弱的短期术前干预是否有助于降低手术风险尚不清楚。本研究的目的是确定在胸外科门诊就诊的衰弱和衰弱前期患者中,能够从衰弱减轻干预中获益的患者比例。
在一家单中心胸外科门诊进行了一项前瞻性队列研究。从2014年10月1日起,纳入年龄60岁及以上且同意接受筛查的手术候选患者。采用改良版的弗里德衰弱表型标准对患者进行筛查:虚弱(握力)、步态缓慢(15英尺步行)、非故意体重减轻、自我报告的疲劳以及自我报告的低体力活动(老年人体力活动量表)。当参与者表现出一至两个衰弱特征时,确定为衰弱前期;当参与者表现出三至五个衰弱特征时,确定为衰弱。
180例符合条件的患者中,126例同意参与,125例完成筛查。39名参与者(31%)无衰弱,71名(57%)为衰弱前期,15名(12%)为衰弱。疲劳是最常见的衰弱症状(34%)。衰弱患病率在男性和女性之间无显著差异(男性:10%,女性:14%;p = 0.75)。
我们发现,在被视为胸外科手术候选患者中,衰弱前期和衰弱患者的比例较高。这一发现表明衰弱可能未得到充分认识。大量患者可能适合接受术前衰弱减轻干预。