Favara B E, Feller A C, Pauli M, Jaffe E S, Weiss L M, Arico M, Bucsky P, Egeler R M, Elinder G, Gadner H, Gresik M, Henter J I, Imashuku S, Janka-Schaub G, Jaffe R, Ladisch S, Nezelof C, Pritchard J
National Institutes of Health, Rocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, Hamilton, MT 59840-2999, USA.
Med Pediatr Oncol. 1997 Sep;29(3):157-66. doi: 10.1002/(sici)1096-911x(199709)29:3<157::aid-mpo1>3.0.co;2-c.
Pathologists and pediatric hematologist/ oncologists of the World Health Organization's Committee on Histiocytic/Reticulum Cell Proliferations and the Reclassification Working Group of the Histiocyte Society present a classification of the histiocytic disorders that primarily affect children. Nosology, based on the lineage of lesional cells and biological behavior, is related to the ontogeny of histiocytes (macrophages and dendritic cells of the immune system). Dendritic cell-related disorders of varied biological behavior are dominated by Langerhans cell histiocytosis, but separate secondary proliferations of dendritic cells must be differentiated. Juvenile xanthogranuloma represents a disorder of dermal dendrocytes, another dendritic cell of skin. The hemophagocytic syndromes are the most common of the macrophage-related disorders of varied biological behavior. Guidelines for distinguishing the exceedingly rare malignant diseases of histiocytes from large cell lymphomas through the use of a battery of special studies are provided.
世界卫生组织组织细胞/网状细胞增殖委员会以及组织细胞协会重新分类工作组的病理学家和儿科血液肿瘤学家提出了主要影响儿童的组织细胞疾病分类。基于病变细胞谱系和生物学行为的疾病分类学与组织细胞（免疫系统的巨噬细胞和树突状细胞）的个体发生有关。具有不同生物学行为的树突状细胞相关疾病以朗格汉斯细胞组织细胞增生症为主，但必须区分树突状细胞单独的继发性增殖。幼年性黄色肉芽肿代表皮肤另一种树突状细胞——真皮树突状细胞的疾病。噬血细胞综合征是具有不同生物学行为的巨噬细胞相关疾病中最常见的。通过一系列特殊研究提供了区分极其罕见的组织细胞恶性疾病与大细胞淋巴瘤的指南。
