TGF-β Signaling: New Insights Into Aortic Aneurysms.
作者信息
Thatcher Sean E
机构信息
Graduate Center for Nutritional Sciences, Room 559, Charles T. Wethington Building, 900 S. Limestone, University of Kentucky, Lexington, KY 40536, USA.
出版信息
EBioMedicine. 2016 Oct;12:24-25. doi: 10.1016/j.ebiom.2016.09.026. Epub 2016 Oct 3.
Abstract
摘要
相似文献
1
TGF-β Signaling: New Insights Into Aortic Aneurysms.转化生长因子-β信号传导：对主动脉瘤的新见解
EBioMedicine. 2016 Oct;12:24-25. doi: 10.1016/j.ebiom.2016.09.026. Epub 2016 Oct 3.
2
Defective Connective Tissue Remodeling in Smad3 Mice Leads to Accelerated Aneurysmal Growth Through Disturbed Downstream TGF-β Signaling.Smad3 基因缺陷型小鼠的结缔组织重构缺陷导致下游 TGF-β 信号通路紊乱，进而加速动脉瘤生长。
EBioMedicine. 2016 Oct;12:280-294. doi: 10.1016/j.ebiom.2016.09.006. Epub 2016 Sep 10.
3
Increased TGF-β Signaling Precedes Aneurysm Formation in SMAD3 Deficient Mice.在SMAD3基因缺陷小鼠中，转化生长因子-β信号增强先于动脉瘤形成。
EBioMedicine. 2016 Oct;12:26-27. doi: 10.1016/j.ebiom.2016.09.033. Epub 2016 Oct 5.
4
Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice.Smad3信号通路在肥胖糖尿病小鼠中促进纤维化，同时维持心脏和主动脉的形态。
Circ Heart Fail. 2015 Jul;8(4):788-98. doi: 10.1161/CIRCHEARTFAILURE.114.001963. Epub 2015 May 18.
5
Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis.SMAD3 基因突变可导致综合征型主动脉瘤和夹层，伴发病症有早发性骨关节炎。
Nat Genet. 2011 Feb;43(2):121-6. doi: 10.1038/ng.744. Epub 2011 Jan 9.
6
The TGF-β pathway plays a key role in aortic aneurysms.TGF-β 通路在主动脉瘤中起着关键作用。
Clin Chim Acta. 2020 Feb;501:222-228. doi: 10.1016/j.cca.2019.10.042. Epub 2019 Nov 9.
7
TGF-β signaling in aortic aneurysm: another round of controversy.TGF-β 信号在主动脉瘤中的作用：又一轮争议。
J Genet Genomics. 2010 Sep;37(9):583-91. doi: 10.1016/S1673-8527(09)60078-3.
8
Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.Smad3基因缺陷的软骨细胞具有增强的骨形态发生蛋白（BMP）信号传导和加速的分化。
J Bone Miner Res. 2006 Jan;21(1):4-16. doi: 10.1359/JBMR.050911. Epub 2005 Sep 19.
9
The Pathogenic Transforming Growth Factor-β Overdrive Hypothesis in Aortic Aneurysms and Dissections: A Mirage?主动脉瘤和夹层中致病性转化生长因子-β 过度驱动假说：海市蜃楼？
Circ Res. 2017 May 26;120(11):1718-1720. doi: 10.1161/CIRCRESAHA.116.310371.
10
Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria.通过敲除小鼠体内的Smad3来干扰转化生长因子-β信号传导，可限制糖尿病性肾小球硬化，而不影响蛋白尿。
Am J Physiol Renal Physiol. 2007 Nov;293(5):F1657-65. doi: 10.1152/ajprenal.00274.2007. Epub 2007 Sep 5.
引用本文的文献
1
Editorial: Chronic inflammation and pharmacological interventions in cardiovascular diseases.社论：心血管疾病中的慢性炎症与药物干预
Front Pharmacol. 2022 Aug 24;13:993569. doi: 10.3389/fphar.2022.993569. eCollection 2022.
2
Transforming Growth Factor-β1 Inhibits Pseudoaneurysm Formation After Aortic Patch Angioplasty.转化生长因子-β1 抑制主动脉补片血管成形术后假性动脉瘤的形成。
Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):195-205. doi: 10.1161/ATVBAHA.117.310372. Epub 2017 Nov 16.
本文引用的文献
1
Defective Connective Tissue Remodeling in Smad3 Mice Leads to Accelerated Aneurysmal Growth Through Disturbed Downstream TGF-β Signaling.Smad3 基因缺陷型小鼠的结缔组织重构缺陷导致下游 TGF-β 信号通路紊乱，进而加速动脉瘤生长。
EBioMedicine. 2016 Oct;12:280-294. doi: 10.1016/j.ebiom.2016.09.006. Epub 2016 Sep 10.
2
Dimorphic effects of transforming growth factor-β signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndrome.转化生长因子-β信号在小鼠主动脉瘤进展过程中的双相作用提示了马凡综合征的联合治疗方案。
Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):911-7. doi: 10.1161/ATVBAHA.114.305150. Epub 2015 Jan 22.
3
Connective tissue disorders and cardiovascular complications: the indomitable role of transforming growth factor-beta signaling.结缔组织疾病与心血管并发症：转化生长因子-β信号的不屈角色。
Adv Exp Med Biol. 2014;802:107-27. doi: 10.1007/978-94-007-7893-1_8.
4
GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency.GM-CSF 导致 SMAD3 缺陷型主动脉瘤的发生。
J Clin Invest. 2013 May;123(5):2317-31. doi: 10.1172/JCI67356. Epub 2013 Apr 15.
5
Targeting the TGFβ signalling pathway in disease.靶向疾病中的 TGFβ 信号通路。
Nat Rev Drug Discov. 2012 Oct;11(10):790-811. doi: 10.1038/nrd3810. Epub 2012 Sep 24.
6
Aneurysm-osteoarthritis syndrome with visceral and iliac artery aneurysms.动脉瘤性骨关节炎综合征伴内脏和髂动脉动脉瘤。
J Vasc Surg. 2013 Jan;57(1):96-102. doi: 10.1016/j.jvs.2012.06.107. Epub 2012 Sep 11.
7
Aggressive cardiovascular phenotype of aneurysms-osteoarthritis syndrome caused by pathogenic SMAD3 variants.由致病性 SMAD3 变异引起的动脉瘤-骨关节炎综合征的侵袭性心血管表型。
J Am Coll Cardiol. 2012 Jul 31;60(5):397-403. doi: 10.1016/j.jacc.2011.12.052. Epub 2012 May 23.
8
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome.氯沙坦是一种血管紧张素Ⅱ1型受体（AT1）拮抗剂，可在马方综合征小鼠模型中预防主动脉瘤形成。
Science. 2006 Apr 7;312(5770):117-21. doi: 10.1126/science.1124287.
9
Marfan's syndrome.马方综合征
Lancet. 2005 Dec 3;366(9501):1965-76. doi: 10.1016/S0140-6736(05)67789-6.
10
Orchidectomy, but not ovariectomy, regulates angiotensin II-induced vascular diseases in apolipoprotein E-deficient mice.睾丸切除术而非卵巢切除术可调节载脂蛋白E缺陷小鼠中血管紧张素II诱导的血管疾病。
Endocrinology. 2004 Aug;145(8):3866-72. doi: 10.1210/en.2003-1615. Epub 2004 Apr 22.
Zotero 插件