Akaishi Yu, Matsumoto Tetsuya, Harada Yoshimi, Hirayama Yoji
Department of Primary Care and General Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Department of Microbiology, Tokyo Medical University, Tokyo, Japan.
Int J Infect Dis. 2016 Nov;52:55-58. doi: 10.1016/j.ijid.2016.10.002. Epub 2016 Oct 6.
As the characteristics and accuracy of rapid influenza detection tests (RIDTs) vary, the development of a high-performance RIDT has been eagerly anticipated. In this study, the new RIDT GOLD SIGN FLU and the existing RIDT Quick Navi-Flu were evaluated in terms of detecting the antigens of influenza viruses A and B in Japanese adults with influenza-like symptoms. The study was performed from December 2013 to March 2014. Among the 123 patients from whom nasopharyngeal swab specimens were collected, 59 tested positive by viral isolation as the gold standard method (influenza A, n=38; influenza B, n=21). For GOLD SIGN FLU, the sensitivities were 73.7% and 81.0%, and the specificities were 97.6% and 98.0% for influenza A and B, respectively. For Quick Navi-Flu, the sensitivities were 86.8% and 85.7%, and the specificities were 98.8% and 100% for influenza A and B, respectively. The time to the appearance of the line on the test strip was less than 3min for influenza A and less than 2min for influenza B with both RIDTs in more than 90% of cases. GOLD SIGN FLU was useful for diagnosing influenza A, and the result was readily available for influenza B particularly among adult patients. Quick Navi-Flu showed better sensitivities and specificities than GOLD SIGN FLU.
由于快速流感检测试验（RIDTs）的特性和准确性各不相同，人们一直热切期待高性能RIDT的开发。在本研究中，对新型RIDT GOLD SIGN FLU和现有的RIDT Quick Navi-Flu在检测有流感样症状的日本成年人中甲型和乙型流感病毒抗原方面进行了评估。该研究于2013年12月至2014年3月进行。在收集了鼻咽拭子标本的123例患者中，59例通过病毒分离检测呈阳性，病毒分离作为金标准方法（甲型流感，n = 38；乙型流感，n = 21）。对于GOLD SIGN FLU，甲型和乙型流感的敏感性分别为73.7%和81.0%，特异性分别为97.6%和98.0%。对于Quick Navi-Flu，甲型和乙型流感的敏感性分别为86.8%和85.7%，特异性分别为98.8%和100%。在超过90%的病例中，两种RIDT检测甲型流感时试纸条上出现条带的时间少于3分钟，检测乙型流感时少于2分钟。GOLD SIGN FLU对诊断甲型流感有用，对乙型流感尤其是成年患者而言结果可快速获得。Quick Navi-Flu的敏感性和特异性优于GOLD SIGN FLU。
