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本文引用的文献

1
Age of transfused blood in critically ill adults.危重症成人输注血液的年龄。
N Engl J Med. 2015 Apr 9;372(15):1410-8. doi: 10.1056/NEJMoa1500704. Epub 2015 Mar 17.
2
Endogenous microparticles drive the proinflammatory host immune response in severely injured trauma patients.内源性微粒驱动严重创伤患者的促炎宿主免疫反应。
Shock. 2015 Apr;43(4):317-21. doi: 10.1097/SHK.0000000000000321.
3
Platelet-derived microparticles induce polymorphonuclear leukocyte-mediated damage of human pulmonary microvascular endothelial cells.血小板衍生微粒诱导多形核白细胞介导的人肺微血管内皮细胞损伤。
Transfusion. 2015 May;55(5):1051-7. doi: 10.1111/trf.12952. Epub 2015 Jan 6.
4
Microparticles mediate hepatic ischemia-reperfusion injury and are the targets of Diannexin (ASP8597).微粒介导肝脏缺血再灌注损伤，且是Diannexin（ASP8597）的作用靶点。
PLoS One. 2014 Sep 15;9(9):e104376. doi: 10.1371/journal.pone.0104376. eCollection 2014.
5
Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing.通过透射电子显微镜、流式细胞术、纳米颗粒跟踪分析和电阻脉冲感应测定外泌体和微泡的粒径分布。
J Thromb Haemost. 2014 Jul;12(7):1182-92. doi: 10.1111/jth.12602. Epub 2014 Jun 19.
6
The pro-inflammatory potential of microparticles in red blood cell units.红细胞单位中微粒的促炎潜力。
Transfus Med. 2014 Jun;24(3):176-81. doi: 10.1111/tme.12123. Epub 2014 May 2.
7
Erythrocyte-derived microvesicles amplify systemic inflammation by thrombin-dependent activation of complement.红细胞衍生的微囊泡通过凝血酶依赖性补体激活放大全身炎症反应。
Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):313-20. doi: 10.1161/ATVBAHA.113.302378. Epub 2013 Dec 5.
8
The relationship between intraoperative blood transfusion and postoperative systemic inflammatory response syndrome.术中输血与术后全身炎症反应综合征的关系。
Am J Surg. 2013 Apr;205(4):457-65. doi: 10.1016/j.amjsurg.2012.07.042. Epub 2013 Feb 12.
9
Elevated levels of thrombin-generating microparticles in stored red blood cells.储存的红细胞中促凝血酶生成微粒的水平升高。
Vox Sang. 2013 Jul;105(1):11-7. doi: 10.1111/vox.12014. Epub 2013 Jan 25.
10
Intraoperative blood transfusion of one or two units of packed red blood cells is associated with a fivefold risk of stroke in patients undergoing elective carotid endarterectomy.在择期颈动脉内膜切除术的患者中，输注 1 或 2 单位的浓缩红细胞会使中风风险增加五倍。
J Vasc Surg. 2013 Feb;57(2 Suppl):53S-7S. doi: 10.1016/j.jvs.2012.07.059.

红细胞制品中的细胞外囊泡会引发强烈的促炎宿主反应，这取决于数量和储存时间。

Extracellular Vesicles from Red Blood Cell Products Induce a Strong Pro-Inflammatory Host Response, Dependent on Both Numbers and Storage Duration.

作者信息

Straat Marleen, Böing Anita N, Tuip-De Boer Anita, Nieuwland Rienk, Juffermans Nicole P

机构信息

Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands; Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands.

Laboratory of Experimental Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands.

出版信息

Transfus Med Hemother. 2016 Jul;43(4):302-305. doi: 10.1159/000442681. Epub 2015 Dec 16.

DOI:10.1159/000442681
PMID:27721707
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5040938/
Abstract

BACKGROUND

Transfusion of red blood cells (RBCs) is associated with adverse outcome, but the causative factor is unknown. Extracellular vesicles (EVs) have pro-inflammatory properties. We hypothesized that EVs released from both fresh and stored RBC products can induce a host inflammatory response in a dose-dependent manner.

METHODS

Whole blood was incubated with supernatant from RBC units stored for different time periods, either containing (different numbers of) EVs or depleted from EVs.

RESULTS

Incubation with both fresh and stored supernatant containing EVs induced a strong host response with production of TNF, IL-6 and IL-8. In supernatant depleted from EVs, this host response was completely abrogated. IL-10 levels were not affected. EV-induced host response was both dependent on the number of EVs as well as on storage time.

CONCLUSIONS

EVs from both fresh and stored RBC units illicit a strong inflammatory host response in recipients and may therefore contribute to adverse outcome of RBC transfusion.

摘要

背景

输注红细胞（RBC）与不良后果相关，但致病因素尚不清楚。细胞外囊泡（EVs）具有促炎特性。我们假设新鲜和储存的RBC制品释放的EVs可诱导宿主产生剂量依赖性炎症反应。

方法

将全血与储存不同时间段的RBC单位上清液孵育，上清液含有（不同数量的）EVs或不含EVs。

结果

与含有EVs的新鲜和储存上清液孵育均诱导宿主产生强烈反应，产生肿瘤坏死因子（TNF）、白细胞介素-6（IL-6）和白细胞介素-8（IL-8）。在不含EVs的上清液中，这种宿主反应完全消除。白细胞介素-10（IL-10）水平不受影响。EV诱导的宿主反应既取决于EV的数量，也取决于储存时间。

结论

新鲜和储存的RBC单位中的EVs在受者中引发强烈的炎症宿主反应，因此可能导致RBC输血的不良后果。