一种生物素引导的甲醛传感器，可选择性检测癌细胞和组织中的内源性浓度。
A biotin-guided formaldehyde sensor selectively detecting endogenous concentrations in cancerous cells and tissues.
作者信息
Lee Yun Hak, Tang Yonghe, Verwilst Peter, Lin Weiying, Kim Jong Seung
机构信息
Department of Chemistry, Korea University, Seoul 136-701, Korea.
Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Biological Science and Technology, University of Jinan, Shandong 250022, P. R. China.
出版信息
Chem Commun (Camb). 2016 Sep 13;52(75):11247-11250. doi: 10.1039/c6cc06158c.
A biotin appended formaldehyde sensor was found to specifically visualise both exogenous and endogenous levels of formaldehyde in biotin receptor positive cells over biotin negative cells by means of one- and two-photon excitation. The probe furthermore visualised endogenous levels of formaldehyde in tumour tissue slices up to 70 μm depth.
一种连接生物素的甲醛传感器被发现，通过单光子和双光子激发，能特异性地显示生物素受体阳性细胞中外源性和内源性甲醛水平，且相对于生物素阴性细胞更为明显。此外，该探针还能显示肿瘤组织切片中深度达70μm的内源性甲醛水平。
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